Frontiers in Molecular Neuroscience | Molecular Signalling and Pathways

Original Research

Accepted on 16 Dec 2025

Genetic and Metabolic Inflammation Signatures in Chronic Inflammatory Demyelinating Polyneuropathy: The Role of IL18 Polymorphisms and Short-Chain Fatty Acids

in Molecular Signalling and Pathways

Szymon Andrusiów
Marta Dratwa-Kuzmin
Piotr Lacina
Patrycja Bochen
Klaudia Gładysz
Bogumila Szponar
Magdalena Koszewicz

Frontiers in Molecular Neuroscience

129 views

Original Research

Accepted on 16 Dec 2025

Small molecule FTO inhibitor MO-I-500 protects differentiated SH-SY5Y neuronal cells from oxidative stress

in Molecular Signalling and Pathways

Denise Greco
Zuzana Čočková
Debanjan Das
Akash Shivling Mali
Jiri Novotny
Mark Jon Olsen
Petr Telensky

Frontiers in Molecular Neuroscience

100 views

Review

Accepted on 15 Dec 2025

Role of FK506 Binding Protein 51 in Central Nervous System Diseases

in Molecular Signalling and Pathways

Haokun Peng
Yanhao Wei
Yanmei Qiu
Rentang Bi
Longhai Zeng
Bo Hu
Yanan Li

Frontiers in Molecular Neuroscience

Original Research

Published on 03 Dec 2025

Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity

in Molecular Signalling and Pathways

Natalia Siwecka
Wioletta Rozpȩdek-Kamińska
Michał Golberg
Wojciech Wiese
Grzegorz Galita
Ireneusz Majsterek

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1700897

705 views

Original Research

Published on 02 Dec 2025

Regulation of granin neuropeptide gene expression in human brain during development

in Molecular Signalling and Pathways

Laura L. Demsey
Sonia Podvin
Vivian Hook

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1666795

997 views

Review

Published on 01 Dec 2025

Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis

in Molecular Signalling and Pathways

Walid Idi
Razan Sheta
Abid Oueslati

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1681039

1,238 views

Review

Accepted on 28 Nov 2025

Putative role of TMEM165 in congenital cardiomyopathies

in Molecular Signalling and Pathways

Maria Paula Polónia Gonçalves

Frontiers in Molecular Neuroscience

124 views

Original Research

Accepted on 28 Nov 2025

Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain

in Molecular Signalling and Pathways

Amine Cherif
Amine Bourzam
Zeineb Fridhi
Hanani Boukhawiye
Clement Guillou
Pascal Cosette
Sami Zekri
Jérôme LEPRINCE
David Vaudry
Olfa Masmoudi-Kouki

Frontiers in Molecular Neuroscience

181 views

Editorial

Published on 25 Nov 2025

Editorial: Nutrient signaling and neuroendocrine pathways in brain-organ communication

in Molecular Signalling and Pathways

Hiroyuki Aizawa
Hiroaki Masuzaki

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1711443

632 views

Review

Published on 17 Nov 2025

Alpha-neurexins in health and disease

in Molecular Signalling and Pathways

Nicolas Chofflet
Manni Wang
Mathilde Chofflet
Hideto Takahashi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716782

1,165 views

Brief Research Report

Accepted on 07 Nov 2025

Hsd17b7 undergoes dynamic subcellular localization during Neuro2a differentiation

in Molecular Signalling and Pathways

Matthew Bispo
Ashley Marie Driver

Frontiers in Molecular Neuroscience

249 views

Brief Research Report

Published on 05 Nov 2025

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression

in Molecular Signalling and Pathways

Rafaela Pedro Silva
Till G. A. Mack
Marieluise Kirchner
Philipp Mertins
Britta J. Eickholt
Patricia Kreis

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1697642

1,241 views

Original Research

Published on 05 Nov 2025

Pex1 loss-of-function in zebrafish is viable and recapitulates hallmarks of Zellweger spectrum disorders

in Molecular Signalling and Pathways

Ursula Heins-Marroquin
Zlatan Hodzic
Beatriz Soares Carneiro da Silva
Agnes Hendriks
Floriane Gavotto
Marc O. Warmoes
Lisa Schlicker
Samy Omri
Christian Jäger
Enrico Glaab

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1634536

1,461 views

Original Research

Published on 28 Oct 2025

Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation

in Molecular Signalling and Pathways

Itzhak Fischer
Peter W. Baas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1707820

1,020 views

Original Research

Published on 09 Oct 2025

Neuronal activity-dependent gene expression is stimulus-specific and changes with neuronal maturation

in Molecular Signalling and Pathways

Jeronimo Lukin
Maximiliano S. Beckel
Olivia Pedroncini
Sebastian A. Giusti
Giuliana C. Di Mauro
Ivana Marcela Linenberg
Ines Lucia Patop
Ariel Chernomoretz
Antonia Marin-Burgin
Sebastian Kadener

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1609772

2,883 views

Original Research

Published on 03 Oct 2025

SIRT3 inhibits autophagy-dependent ferroptosis of HUVECs in the progression of pregnancy-induced hypertension by activating the PI3K/Akt/mTOR axis

in Molecular Signalling and Pathways

Yanchuan Li
Yanfeng Liu
Ziyun Shi
Meiqing He

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1620184

2,049 views

Original Research

Published on 22 Sep 2025

Cross-disease biomarker identification reveals shared diagnostic biomarkers for IVDD and NAFLD via bulk and single-cell RNA sequencing

in Molecular Signalling and Pathways

Jiasen Wei
Chenglong Ji
Lina Liu
Chen Yan
Linhui Han
Wenbo Lin
Ximing Xu
Kaiqiang Sun

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1639705

2,737 views

Review

Published on 22 Sep 2025

Advances in research on propofol-induced postoperative cognitive dysfunction via Piezo channels

in Molecular Signalling and Pathways

Han Xue
Xiaoyu Zhang
Chenxu Chou
Yulong Jia
Chunguang Hao
Xiaguang Duan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1668523

3,174 views

Original Research

Published on 15 Sep 2025

Tamoxifen attenuates manganese-induced dysregulation of neuronal REST via the genomic ER-α mechanism

in Molecular Signalling and Pathways

Alexis Digman
Edward Pajarillo
Sanghoon Kim
Itunu Ajayi
Deok-Soo Son
Michael Aschner
Eunsook Lee

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1648904

2,164 views

Correction

Published on 09 Sep 2025

Correction: S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation

in Molecular Signalling and Pathways

Xin-Ru Wang
Shan-Shan Huang
Meng Wang
Jin-Hong Lin
Jian-Tao Wang
Jiao-Qi Ren
Cheng-Feng He
Wen-Jiao Xue
Yin Wang
Xue-Chun Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1688881

1,795 views

Original Research

Published on 04 Sep 2025

Nfkbia-driven neuroinflammatory pathways mediate depression following spinal cord injury

in Molecular Signalling and Pathways

Aichun Yang
Guoyuan He
Yanling Song
Yujun Wen
Hechun Xia
Shenhong Gu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1596649

2,589 views

Review

Published on 29 Aug 2025

Peroxisomes as emerging clinical targets in neuroinflammatory diseases

in Molecular Signalling and Pathways

Andrej Roczkowsky
Richard A. Rachubinski
Tom C. Hobman
Christopher Power

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1642590

3,166 views

Original Research

Published on 18 Aug 2025

KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q

in Molecular Signalling and Pathways

Jinglin Ji
Catherine Choi
Christopher E. Bope
Jacob S. Dengler
Stephen J. Moss
Joshua L. Smalley

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1645428

2,371 views

Original Research

Published on 08 Aug 2025

S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation

in Molecular Signalling and Pathways

Xin-Ru Wang
Shan-Shan Huang
Meng Wang
Jin-Hong Lin
Jian-Tao Wang
Jiao-Qi Ren
Cheng-Feng He
Wen-Jiao Xue
Yin Wang
Xue-Chun Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1617543

2,516 views

1,623 articles

articles

Genetic and Metabolic Inflammation Signatures in Chronic Inflammatory Demyelinating Polyneuropathy: The Role of IL18 Polymorphisms and Short-Chain Fatty Acids

Small molecule FTO inhibitor MO-I-500 protects differentiated SH-SY5Y neuronal cells from oxidative stress

Role of FK506 Binding Protein 51 in Central Nervous System Diseases

Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity

Regulation of granin neuropeptide gene expression in human brain during development

Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis

Putative role of TMEM165 in congenital cardiomyopathies

Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain

Editorial: Nutrient signaling and neuroendocrine pathways in brain-organ communication

Alpha-neurexins in health and disease

Hsd17b7 undergoes dynamic subcellular localization during Neuro2a differentiation

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression

Pex1 loss-of-function in zebrafish is viable and recapitulates hallmarks of Zellweger spectrum disorders

Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation

Neuronal activity-dependent gene expression is stimulus-specific and changes with neuronal maturation

SIRT3 inhibits autophagy-dependent ferroptosis of HUVECs in the progression of pregnancy-induced hypertension by activating the PI3K/Akt/mTOR axis

Cross-disease biomarker identification reveals shared diagnostic biomarkers for IVDD and NAFLD via bulk and single-cell RNA sequencing

Advances in research on propofol-induced postoperative cognitive dysfunction via Piezo channels

Tamoxifen attenuates manganese-induced dysregulation of neuronal REST via the genomic ER-α mechanism

Correction: S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation

Nfkbia-driven neuroinflammatory pathways mediate depression following spinal cord injury

Peroxisomes as emerging clinical targets in neuroinflammatory diseases

KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q

S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation