In the original article, there was a mistake. In the Discussion, “Figure 5” was referenced instead of “Figure 7.”
A correction has been made to the Discussion, paragraph nine:
“In conclusion, our findings indicate that BBB breakdown is a dynamic phenomenon and time-dependent, i.e., it happens at specific time-points of the acute phase of pilocarpine model of epilepsy, recovering in part its integrity afterwards (Figure 7). We show that pilocarpine-induced changes on brain tissue initially increased the permeability of the BBB to micromolecules, and subsequently, after SE, the BBB breakdown to macromolecules occurred. Although the BBB permeability to macromolecules is restored 24 h after SE, the leakage of micromolecules persists and the consequences of BBB degradation are widely disseminated in the brain, which in turn may induce further episodes of BBB breakdown. Together, our data reveal the existence of a temporal window of BBB dysfunction during the acute phase of the pilocarpine model that is important for the development of therapeutic strategies to prevent the epileptogenesis.”
Additionally, Figure 7 was not provided in the original manuscript. Figure 7 appears below.
Figure 7
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Summary
Keywords
epilepsy, blood-brain barrier, pilocarpine, status epilepticus, Evans blue, sodium fluorescein
Citation
Mendes NF, Pansani AP, Carmanhães ERF, Tange P, Meireles JV, Ochikubo M, Chagas JR, da Silva AV, Monteiro de Castro G and Le Sueur-Maluf L (2019) Corrigendum: The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent. Front. Neurol. 10:603. doi: 10.3389/fneur.2019.00603
Received
22 April 2019
Accepted
22 May 2019
Published
10 June 2019
Approved by
Frontiers Editorial Office, Frontiers Media SA, Switzerland
Volume
10 - 2019
Updates
Copyright
© 2019 Mendes, Pansani, Carmanhães, Tange, Meireles, Ochikubo, Chagas, da Silva, Monteiro de Castro and Le Sueur-Maluf.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Luciana Le Sueur-Maluf luciana.maluf@unifesp.br;lucianamaluf@gmail.com
†Present Address: Natália Ferreira Mendes, Faculdade de Enfermagem, Universidade Estadual de Campinas, Campinas, Brazil
This article was submitted to Epilepsy, a section of the journal Frontiers in Neurology
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