Abstract
A Solitary Fibrous Tumor (SFT) is a rare, aggressive, and metastasis- and recurrence- prone mesenchymal tumor. In this case report and review, we describe a rare instance of intracranial SFT, discovered for the first time. It was discovered in 2008 and following total surgical removal, the pathology was categorized as hemangiopericytoma cell tumor (HPC) at the time by WHO tumor criteria. An imaging review 8 months after surgery revealed a tumor recurrence: combined radiation and gamma-knife therapy was continued throughout this time. The tumor did not metastasis until June 2018 when it presented in the pancreas with ruptured bleeding and a postoperative pathology was suggestive of SFT. Fortunately, the patient is still alive nearly 3 years after the 2020 surgery, after staged surgical resection and combined multimedia therapy, with no imaging or clinical evidence of a recurrent intracranial primary lesions. To our knowledge, there is no previous record of using a combined treatment modality for Intracranial Solitary Fibrous Tumor (ISFT). Combined with an account of the patient's experience, we empirically describe a combined approach with a preference for gross-total resection (GTR), supplemented by multimodal assistance with stereotactic (radiotherapy), gamma knife (GK), molecular targeting, and immunization for patients admitted acutely, with accurate preoperative identification and aggressive management after intraoperative case response to maximize treatment of recurrent ISFT and improve prognosis. We recommend multimodal management for SFT with prolonged-term recurrence and metastases, both for the control benefits of GTR, RT, or GK for local recurrence and for the positive prognosis of targeted and immune metastases.
1. Introduction
A Solitary Fibrous Tumor (SFT) is a mesenchymal tumor characterized by specialized fibroblasts of intermediate biological potential. It is usually found in pleura (). Cases of SFT occurring in the central nervous system (CNS SFTs) were first reported by Carneiro and Scheithauer in 1996 (). Another term, “hemangiopericytoma,” is used to describe an SFT and hemangiopericytoma cell tumor (HPC), which has been categorized as a distinct entity according to World Health Organization (WHO) CNS tumor classification criteria since 2016. Since an increasing number of studies have demonstrated that SFTs and HPCs have similar immunohistochemical profiles, they are now collectively referred to as SFTs by the WHO (2021). Among all cases reported to date, intracranial solitary fibrous tumors (ISFTs) are rare, accounting for ~1%−4% of intracranial tumors (). Female and male patients are equally likely to be affected, with onset generally occurring between the age of 51 and 60 (). SFTs are more likely to recur and metastasize compared with other tumors. Based on follow-up data, the rate of recurrence is as high as 75% after 10 years of disease (). The rate of extracranial metastasis is ~13–55% (the metastasis rate was about 11.1–57%) (), and the median survival rate after metastasis is between 22 and 46 months ().
Currently, the main clinical treatment is based on GTR that prioritizes neurological functions, supplemented by multi-mode therapy such as stereotaxis (radiotherapy), GK, molecular targeting, and immunization, etc. In this article, we describe a rare and exceptional case of ISFT active for up to 14 years, with multiple, recurrent, and systemic metastases is presented, including the patient's complete medical history and clinical trajectory. By collecting and studying relevant literature, further information on nomenclature grading, recurrence and survival, diagnosis, multimodal treatment, and prognosis of ISFT is discussed. The purpose of this article is to provide some references and suggestions for the management of these rare clinical cases.
2. Case
A 64-year-old female patient visited the orthopedic department of Guangdong Provincial Hospital of Traditional Chinese Medicine in China on October 7, 2020, due to repeated left lower extremity paresthesia and limited movement. The patient was in a normal state of consciousness during the examination, while declining cognitive, speech function, and the muscle strength of the right limb was 5-grade. Meanwhile, the magnetic resonance imaging (MRI) of the lumbar spine (Figure 1) showed a soft tissue mass shadow on the left side of the T11 adnexa. A cranial MRI (Figure 1) also revealed several abnormal signal shadows in the left frontal lobe and bilateral parieto-occipital lobes. The patient underwent a complete positron emission tomography (PET) scan that revealed multiple metastases throughout the body (Table 1).
Figure 1
Table 1
| Time | Diagnosis | Location | Size |
|---|---|---|---|
| Oct 2020 | Systemic widespread secondary malignancy (SFT) | Both lungs | 1.3 cm (Multiple) |
| Left posterior 10th rib | 5.2 x 5.1 cm (Maximum cross section) | ||
| L2 vertebra | / | ||
| Right sacrum | / | ||
| Bilateral iliacus | / | ||
| Mar 2021 | Systemic widespread secondary malignancy (SFT) | Subsurface S6 envelope of the liver | 2.9 x 2.5 cm |
| Right lower abdominal wall | / | ||
| Left superior femur | Multiple |
The location and times of metastases in this case of malignant SFT.
SFT, solitary fibrous tumor; WHO, World Health Organization.
In 2008, the patient had received the first treatment that was an excision of the left occipital region 14 years previously, which had been identified as having an HPC of grade II-III. Radiation therapy (RT) was then chosen by the patient after surgery. After 2 months, no sign of recurrence was discovered in the follow-up examination. Nevertheless, in March 2009, a recurrence was detected in the primary focus. The patient underwent GK following advice from an external neurosurgeon. In follow-up examinations, neither the patient's clinical symptoms nor the tumor size increased significantly. In February 2018, the patient received GK (left frontal and left temporal lesions, 40% isometric curve, 14–16 Gy peripheral dose, 35–40 Gy central dose).
A partial pancreatectomy and splenectomy were performed on the patient in our hospital in June 2018 for a caudal pancreatic occlusion combined with bleeding (Figure 2). The immunohistochemical results (Figure 2) were positive for Vim, SMA, and B-catenin (plasma), had a focal positive result for CD34, CD99, and S-100, a weak positive result for ERG, Bc1-2, and FLI-1, and a negative result for CD117, CD56, STAT6, and Ki67 index 10%. The pathological findings at that time suggested atypical and malignant SFT (metastases).
Figure 2
In 2020, a mass in the lumbar spine was investigated as a possible metastatic tumor based on the patient's medical history. The patient was transferred from orthopedics to neurosurgery because of the complex conditions, and three frontotemporal tumors were removed. The swelling was fish-like in appearance, gray in color, and slightly soft in texture (Figure 3).
Figure 3
The pathology of the tumor cells revealed that cells were solid and grew in a lamellar way (Figure 3). The cells were also short spindle or ovoid in shape, with inconspicuous nucleoli and 6–15 nuclear fission images/10 HPF. Immunohistochemical staining suggested positive results for Vim, ERG (vascular), and CD99, and had scattered or localized positivity for S-100, CD34, NSE, and STAT6. The Ki67 index increased significantly to 15%. According to the 2016 WHO classification system for tumors of the central nervous system and in conjunction with the pathology, the final diagnosis was ISFT (WHO grade III). The patient was hospitalized on November 11, 2020, after experiencing a sudden onset of confusion. Emergency cranial computed tomography (CT) confirmed the left remaining occipital lobe mass (Figure 4). We performed total resection of the tumor. The pathological nature of the tumor was like that of the previously resected tumor, which was consistent with SFT, and postoperative MRI confirmed total tumor resection (Figure 5). Neurologically, the patient improved significantly following the operation, and muscle strength and tone returned to normal. The patient was discharged from the hospital for regular follow-up CT/MRI imaging. Afterward, liver metastasis and metastasis in the right lower abdominal wall were found by abdominal CT in March 2021 (Table 1). Considering the patient's complicated medical history, including multiple metastases throughout the body, several surgeries, and recurrence, as well as the fact that the patient had received surgery and radiation, Anlotinib targeted therapy (March 2021) and Sintilimab immunotherapy (May 2021) were given by the oncologists consecutively. The patient's treatment was well-tolerated, with no particular adverse reactions, and they are currently stable and progressing slowly. During follow-up in July 2021, the patient was treated with GK again in another hospital, and the general condition remained stable, with no obvious signs of recurrence of intracranial lesions (Figure 5).
Figure 4
Figure 5
Earlier medical records cannot be retrieved due to the complexity of the patient's medical history, the long-time span, and unsolvable storage issues related to medical equipment. Applying the data in Table 2, an attempt was made to review the patient's entire course of illness.
Table 2
| Time | Tumor location | Size | Treatment | Immuunohistochemistry (+) | WHO grade |
|---|---|---|---|---|---|
| Jul 2008 | left occipital | 6.9 x 4.4 cm | GTR+RT | CD34,Vim | II-III |
| Mar 2009 | left occipital (Recurrence) | 1.5 x 2.0 x 1.9 cm | GK | N,D | N,D |
| Feb 2018 | left frontal, left temporal lesions | N,D | GK | N,D | N,D |
| Jun 2018 | Pancreas | 6.1 x 13.5 x 8.0 cm | GTR | CD34, B-catenin, Vim, SMA, CD99, S-100 | III |
| Dec 2018 | left frontal lobe | 0.4 x 0.7 cm | N,D | N,D | N,D |
| Left temporal lobe | 0.4 x 0.5 cm | N,D | N,D | N,D | |
| Aug 2019 | Superior sagittal sinus | 1.4 x 2.7 x 1.3 cm | RT | N,D | N,D |
Timeline of the patient's illness.
GTR, gross total removal; RT, Radiotherapy; N,D, no data; WHO, World Health Organization; CD34, cluster of differentiation 34; CD99, cluster of differentiation 99; Vim, vimentin; S-100, s-100 protein; SMA, Smooth muscle actin.
3. Discussion
3.1. Naming and grading
There is a long history of coexistence between SFT and HPC in literature. Lietaud first mentioned SFT in the pleura in 1767 (), and Stout and Murray proposed HPC in 1942 (). According to the 2007 WHO classification of central nervous system tumors, HPC and SFT are distinct lesions (). By 2012 the WHO classification of soft tissue and bone tumors integrated SFT and HPC into one disease entity (). New research in 2013 revealed that SFT exhibits features of HPC histology and immunohistochemistry. Moreover, NAB2-STAT6[(nerve growth factor induced gene A binding protein 2)—signal transducers and activators of tranion 6, STAT6)] gene fusions with translocations on chromosome 12q13 have frequently been detected (). It was not until 2016 that low-grade SFTs, high-grade HPCs, and interstitial HPCs were considered to be a single category, SFT/HPC, in the WHO classification (). The terminology “SFT” was applied in WHO classification in the latest 2021 edition, with “HPC” removed (). According to statistics, SFT accounts for ~2% of all primary soft tissue tumors (). SFT occurring in the CNS SFT accounts for only 1% of all primary tumors, and intracranial SFT is even more rare ().
As for the case mentioned, the patient was first diagnosed with HPC grade II–III 14 years ago (2008). After a thoughtful study of the historical complexity of the relationship between SFT and HPC, as well as their eventual unification, a reevaluation of the pathological tissue was obtained during the patient's first surgery (2008), which discovered that the characteristics of the tissue were consistent with the current WHO-SFT grade III criteria. Since no metastases were found on examination at that time, and even though the progression of systemic multiplication was discovered over the subsequent 14-year course of the disease, it is reasonable to assume that the main focus was intracranial.
3.2. Diagnosis
The diagnosis of ISFT was mainly based on pathology or immunohistochemistry results, with imaging and other tests serving as supplementary diagnostic measures. Pathologically, SFT sections were found to exhibit color changes primarily due to collagen fibers, blood vessels, necrosis, and mucus-like or cystic degeneration. The tumor cells mainly consisted of hyaline or sclerotic collagen fibers arranged in short, randomly oriented bundles, whorls, or nests of predominantly oval or spindle-shaped cells. Moreover, in the tan flesh in cellular tumors or gelatinous in mucinous tumors, the presence of distinct hemorrhagic domains as well as necrosis can be observed (, ). For immunohistochemistry, Schweizer et al. stated in 2013 that the new genotype of NAB2-STAT6 served as the most specific diagnostic marker, possessing a sensitivity and specificity of 97% (). Yoshida et al. () performed STAT6 staining on 49 SFTs in 2014 and demonstrated that 100% were diffusely expressed. In the course of developing immunohistochemical techniques, additional markers that seem to be associated with SFT have been discovered. To date, the immunohistochemical markers CD34, BCL-2, wave protein, and CD99 are almost always expressed positively or strongly positively in SFT (). However, occasionally SMA is also positive (). Furthermore, keratin, actin, junctional protein, epithelial membrane antigen, S-100, BEGF, and EMA are often negative (). It has been reported that CD34 is highly sensitive to SFT, with expression rates of 90–95% (). Additionally, the positive expression rates of CD99 and bcl-2 are 75%−100% and 80%−100%, respectively (). Multiple studies are necessary to validate their potential role. In addition, some recent studies have conducted genetic and molecular analyses of dysregulated angiogenesis for SFT. They found that upregulated of Vascular Endothelial Growth Factor (VEGF) and its receptor VEGFR were associated with activation of the AKT pathway. From this perspective, the tumorigenesis or origin of SFT may be related to the activation of angiogenic signaling pathways (). We believe these findings provide more possibilities for the diagnosis of SFT.
3.3. Recurrence and survival
A high recurrence rate and high tumor mortality are associated with SFT/HPC, which is classified into three grades by the 2016 WHO classification system. Grades II and III of these are more likely to have malignant behavior, as they have greater recurrence rates, extracranial metastases, and higher fatality rates [3]. There have been reports of tumors metastasizing anywhere from 2 to 18 years after resection. The most common is bone metastases with a rate of 19.6%, followed by lung and pleura metastases with a rate of 18.4%, liver with 17.6%, and vertebrae with 14.1% (). The median survival of patients with extracranial metastases is only 4.4 years after the occurrence of extracranial metastases (, , ), of which the rate has been found to be about 13~55% in some literature (, –). Moreover, a retrospective study () found that CD34 negativity was more likely to indicate the presence of head and neck metastases. In this case, the patient was first diagnosed intracranially with SFT 14 years ago (2008), and by 2020, metastases were in the pancreas, lung, liver, bone, and other organs. It is rare for a patient to survive multiple surgeries, radiotherapy, targeted therapy, immunotherapy, and other systemic combination therapies and still be in stable condition.
3.4. Points to consider
In total, 180 pertinent papers were found after screening the literature published in PubMed between 1996 and October 2022 using the common search term Intracranial Solitary Fibrous Tumor (ISFT). The types of literature collected included retrospective analyses and case reports, etc. Three cases were selected after other literature being excluded due to them having incomplete case information and <10 years of survival. The statistical results are presented in Table 3. In light of the literature and the facts of the patient, the following proposition is presented.
Table 3
| Author | Year | Age (years)/gender | Tumor location | Immuunohistochemistry(+) | Treatment | Recurrence(m) | Follow up (m) | Outcome |
|---|---|---|---|---|---|---|---|---|
| Oliveira et al. () | 2017 | 59/M | Lt temporal lobe | CD34, STAT6, Bcl-2, Vim | GTR+RT | 34 | 178 | S |
| Shirakura et al. () | 2022 | 27/F | Rt posterior cranial fossa | CD34 | GTR | N | 288 | S |
| 35/F | Lt posterior fossa | N, D | N,D | Multiple | 264 | D |
Review of previously reported cases of ISFT with survival time≥10 years from 1996 to 2022.
M, Male; F, Female; m, month; N, No; Rt, Right; Lt, Left; N, D, no data; D, Dead; S, survival; GTR, Gross total resection; RT, RadioTherapy; CD34, Cluster of differentiation 34; Bcl-2, B-cell lymphoma 2; STAT6, Signal transducer and activator of transcription 6; Vim, vimentin.
3.4.1. Multimodal treatment
Because of ISFT's low occurrence, evidence for the general treatment of ISFT relies on limited case reports and retrospective studies, and there are no definitive guidelines for the treatment of ISFTs, especially concerning recurrence and metastasis (). The GTR that prioritizes the protection of neurological function is the primary treatment for ISFT. To obtain optimal results, the surgical plan and treatment strategy need to consider the patient's clinical symptoms and imaging characteristics. The progression-free survival (PFS) and overall survival (OS) of GTR are generally better than those of subtotal resection (STR) and partial resection (PR) (). However, surgical resection has uncertain limiting factors. For example, to obtain the optimal surgical program suitable for the patient, most surgeons need to select the method of tumor resection based on the patient's symptoms, imaging features, tumor location, and other factors. Because this is an aggressive and malignant tumor. Surgical resection cannot prevent recurrence or metastasis in ISFT patients. Therefore, postoperative radiotherapy (PORT) is a good option for patients with ISFT. Patients often receive Intensity Modulated Conformal Radiotherapy (IMRT), stereotactic radiosurgery (SRS), and gamma knife treatment postoperatively to reduce recurrence and improve their quality of life (–). Stereotactic radiosurgery (especially GK) has been a promising approach for postoperative treatment of SFT over the past decade, with 3-year progression-free survival rates ranging from 60 to 92% (–). Multi-center studies have also reported that a cumulative radiation dose of GK is associated with the treatment of SFT (, , ). However, Due to the diversity of existing postoperative treatment modalities and the rarity of ISFT, the effect of PORT on the OS of ISFT is still being discussed. Park et al. () found that in patients with locally advanced, recurrent, or metastatic SFT treated with cytotoxic chemotherapy, the tumor response to chemotherapy was poor. The objective response rate was 0% and the median PFS duration, measured from the start of chemotherapy, was 4.6 months. Constantinidouet al. () found that more than 50% of patients progressed with non-first-line chemotherapy and a median PFS of 4.2 months in their study, which provides evidence that conventional palliative chemotherapy is of limited value. These studies have demonstrated weak sensitivity to chemotherapy for metastatic or recurrent SFT. Therefore, the efficacy of conventional chemotherapy in the treatment of recurrent or metastatic ISFT is limited. There is great potential for molecularly targeted therapies with the rapid developments in our understanding of the molecular genetics of tumors. Temozolomide in combination with bevacizumab, pazopanib, sunitinib, and radiotherapy in combination with toremifene have been reported as having been applied in the treatment of SFT (–). They are all beneficial to the PFS and OS of patients. Anlotinib has been reported to have potential therapeutic effects in patients with soft tissue sarcomas and various advanced cancers (, ). In our case, we tried to apply the targeted drug, anlotinib to control ISFT and metastases at related sites. The patient's disease is progressing slowly at present, and we believe that anlotinib may become a new choice for advanced or metastatic ISFT after future large-sample clinical studies. There are, however, some limitations to using molecularly targeted drugs, such as difficulty in screening targets and susceptibility to drug resistance. Immunotherapy is a better option for patients with intolerant advanced tumors, and future use of this approach is promising.
After being diagnosed with ISFT 14 years ago, the patient never stopped fighting the disease and actively cooperated with doctors. Aside from the surgical removal of the primary focus, the patient survived and remained in good condition by taking SRS, IMRT, targeted therapy, immunotherapy, and other treatments in the initial stage.
The patient has witnessed the evolution of SFT treatment and diagnoses over the past few decades. The clinical connotations of SFT have expanded from hypocellular fibrous SFT to stand-alone SFT combined with HPC, and then to mesenchymal SFT which tends to become sarcomatous. On reflection, timely diagnosis, regular follow-ups, and surgical procedures that could preserve neurological function as much as possible are all crucial to the treatment of the patient. Furthermore, aggressive radiotherapy, even the currently popular targeted therapies, and immunotherapy all had a significant impact on the prognosis of the patient. The case provides clinicians with more references and lessons to consider when dealing with patients with SFT.
3.4.2. Prognostic factors
Kim et al. () concluded that the size of the tumor removed is a good predictor of the outcome of SFT. The OS and PFS were longer in the GTR group compared to the STR group according to Melone et al. () in their description of 43 cases (p = 0.047 and p = 0.0025, respectively). Some studies (46) found that the prognosis of a patient may depend on the condition of the interfaces of the tumor and the brain, such as the amount of cranial infiltration, the degree of attachment to the dura mater, and the grade of the tumor. According to a study on ISFT malignancy, low-grade Meningeal Solitary Fibrous Tumors (MSFTs) can transform into high-grade. The malignant progression, possibly associated with mutations in NAB2-STAT6, CDKN2/p16, or the TERT promoter gene, of high-grade is crucial to frequent relapses (). Furthermore, by comparing programmed cell death-1 (PD-1) and its ligand-1 (PD-L1) in 16 patients with ISFT, Kamamoto et al. () found that PD-L1 could be diffusely or strongly expressed. Their research claims that this may lead to extracranial metastasis and that inhibiting immune check targets may be a new way to prevent metastasis, with the potential to improve the prognosis of patients. As part of this literature search, we also found reports indicating that some cases with histological features consistent with the primary lesion had slow disease progression, whereas cases with rapid progression and progression were found to have dedifferentiated histological features and loss of CD34 and Bcl-2 expression (), with reduced or absent CD34 expression indicative of ISFT malignancy or tumor progression (50). The differential expression of these molecular gene proteins may indicate a potential future prognosis for ISFT.
3.4.3. Follow-up
Follow-up and monitoring of SFT are inevitable recommendations (51). According to the research, long-term persistence in follow-up is rare among patients. Approximately 80% of the patients received follow-up. It is believed that the stable condition obtained by the patient is positively connected to uninterruptible follow-up. In the future, reasonably close monitoring and long-term follow-up would be provided to patients so that their prognosis can be improved.
4. Conclusion
ISFT is a very rare intracranial soft tissue tumor that has a high rate of recurrence, metastasis, and death. Currently, pathology and immunohistochemistry are applied in diagnosis. When it comes to treatment, surgical excision is the primary treatment mode, but radiotherapy, targeted therapy, and immunotherapy may be more effective when combined. As SFT survival times increase, it is imperative to maintain close long-term follow-up. Furthermore, tumor “malignancy” seems to be a possible transformation for some patients. Therefore, further investigation is needed to deduce whether a more aggressive approach to tumor management is needed.
Statements
Data availability statement
The original contributions presented in the study are included in the article/Supplementary material, further inquiries can be directed to the corresponding authors.
Ethics statement
Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.
Author contributions
YG, YX, and RX undertook conceptualization, organizing figures, writing and revising, and original manuscript. DX and YS contributed to composing the patient's medical history. ZZ and JL revised the manuscript and collected the data. TH and ZP contributed to administrative, technical and material support, writing, review, and editing. All authors contributed to the article and approved the submitted version.
Funding
The study was supported by the 17th Bajian Talent Project of Guangdong Provincial Hospital of Traditional Chinese Medicine (BJ2022YL06) and the 13th Chaoyang Talent Project of Guangdong Provincial Hospital of Traditional Chinese Medicine (ZY2022YL28).
Acknowledgments
Our authors appreciate the help provided by editors and reviewers in preparing this manuscript.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fneur.2023.1201964/full#supplementary-material
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Summary
Keywords
intracranial solitary fibrous tumor, hemangioepithelial cell tumors, gross total resection, multimodal treatment, follow-up
Citation
Gao Y, Xu Y, Xie R, Shen Y, Xue D, Zhen Z, Lu J, Huang T and Peng Z (2023) A rare case of intracranial solitary fibrous tumor that is still alive after multiple surgical resections: a case report and review of the literature. Front. Neurol. 14:1201964. doi: 10.3389/fneur.2023.1201964
Received
07 April 2023
Accepted
20 June 2023
Published
10 July 2023
Volume
14 - 2023
Edited by
Pasquale Cianci, Azienda Sanitaria Localedella Provincia di Barletta Andri Trani (ASL BT), Italy
Reviewed by
Salvatore Chibbaro, Neurosurgery Department Strasbourg University Hospital, France; Daniele Lavacchi, Careggi University Hospital, Italy
Updates
Copyright
© 2023 Gao, Xu, Xie, Shen, Xue, Zhen, Lu, Huang and Peng.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Tao Huang arteries@163.comZiZhuang Peng being001@qq.com
†These authors have contributed equally to this work
Disclaimer
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