ORIGINAL RESEARCH article
Front. Neurol.
Sec. Sleep Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1499573
Identification and molecular mechanism of palmitoylationrelated biomarkers in obstructive sleep apnea
Provisionally accepted
- 1Chengdu University, Chengdu, China
- 2Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, Sichuan Province, China
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Palmitoylation influences patients with obstructive sleep apnea (OSA) by modulating amyloid-β production. However, the involvement of palmitoylation-related genes (PRGs) in OSA remains unclear. This study, utilizing bioinformatics, aims to investigate this mechanism. Datasets GSE38792 and GSE135917 were retrieved from the Gene Expression Omnibus database. Differentially expressed PRGs (DE-PRGs) were identified through differential expression analysis and weighted gene co-expression network analysis. Candidate genes were pinpointed using the max cluster centrality method in cytoHubba. Biomarkers were subsequently selected through machine learning algorithms, expression profiling, and ROC analysis, with diagnostic potential assessed via a nomogram. Enrichment analysis, molecular regulatory network construction, and drug prediction further elucidated the role of biomarkers in OSA. HIF1A and PDIA3 emerged as potential biomarkers, with the nomogram demonstrating robust predictive accuracy for OSA. Enrichment analysis revealed that HIF1A and PDIA3 were co-enriched in pathways such as ' focal adhesion' , ' olfactory transduction' , ' RNA degradation' , ' spliceosome' , and ' ubiquitin-mediated proteolysis' . A lncRNA-miRNA-mRNA regulatory network was constructed, featuring multiple regulatory pairs, including CYTOR-hsa-miR -1-3p-HIF1A and CYTOR-hsa-miR-1-3p-PDIA3. Additionally, drug prediction analysis identified potential compounds targeting HIF1A, such as klugine, puupehenone, and
Keywords: obstructive sleep apnea, palmitoylation, nomogram, HIF1A, PDIA3
Received: 21 Sep 2024; Accepted: 08 Aug 2025.
Copyright: © 2025 Hong, Zeng, Wang, Kang, Chen, Lan and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yiguang Hong, Chengdu University, Chengdu, China
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