ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1536535
Correlation between neutrophil to high-density lipoprotein cholesterol ratio (NHR) and the adverse prognosis of patients who achieve complete recanalization after thrombectomy for acute large vessel occlusion stroke
Provisionally accepted
- 1Department of Neurology, the Second Hospital of Dalian Medical University, Dalian, China
- 2Department of Neurological Intervention and Neurological Intensive Care, Central Hospital of Dalian University of Technology, Dalian, China
- 3Department of Interventional Therapy, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
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Background: The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) has emerged as a novel inflammatory marker with prognostic significance. This study aims to explore the association between NHR and adverse prognosis in patients with acute large vessel occlusion (LVO) stroke who achieved complete recanalization after mechanical thrombectomy (MT). Methods: This retrospective study analyzed acute ischemic stroke (AIS) patients with LVO who underwent MT at three stroke centers in Dalian, China, between January 2016 and November 2023.Complete recanalization was defined as achieving a modified Thrombolysis in Cerebral Infarction (mTICI) grade 3. Blood parameters were assessed within 24 hours after MT. We compared intergroup differences based on NHR tertiles and employed multivariate logistic regression analysis to assess the relationship between NHR and adverse outcomes.Results: The study included 348 AIS patients with LVO, of whom 215 (61.8%) had adverse clinical outcomes at 90 days. Multivariate logistic regression analysis showed a significant association between elevated NHR and 90-day adverse outcomes (OR2.311, 95% CI 1.248-4.278, p=0.008). A restricted cubic spline curve demonstrated a linear dose-response relationship between NHR and adverse outcomes (P for nonlinearity=0.348). Conclusion: Our findings suggest that an elevated NHR may increase the risk of adverse prognosis following complete recanalization after MT for acute LVO stroke, indicating that NHR could serve as a potential inflammatory marker to identify such patients.
Keywords: Neutrophil to high-density lipoprotein cholesterol ratio, Adverse prognosis, complete recanalization, Mechanical thrombectomy, Large vessel occlusion
Received: 29 Nov 2024; Accepted: 12 May 2025.
Copyright: © 2025 Ci, Li, Wang, Li and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lin Yin, Department of Neurology, the Second Hospital of Dalian Medical University, Dalian, China
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