REVIEW article
Front. Neurol.
Sec. Neuroepidemiology
Relationship between selenium consumption and circulation level and stroke: a systematic review and meta-analysis
Provisionally accepted
- Chaoyang Central Hospital, Chaoyang, Beijing, China
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Abstract Word count: 250 Background:Ischemic stroke represents the predominant subtype among all strokes. Selenium is a crucial trace mineral with potential relevance for the prevention of cerebrovascular disease due to its antioxidant properties. An increasing number of studies have indicated that circulating selenium is associated with ischemic stroke. The goal of this study was to ascertain whether low circulating selenium concentrations are associated with an increased risk of cerebrovascular illness and mortality.Methods: Electronic databases were identified to search for relevant studies about circulating selenium ,dietary selenium intake and ischemic stroke from inception to April 11, 2024. 33 studies with a total of 270621 participants were included into this meta-analysis.Results:1)The aggregated weighted mean difference (WMD) demonstrated that circulating selenium concentrations were markedly reduced in the ischemic stroke cohort relative to the control cohort (WMD = -0.13, 95% confidence interval [CI]: -0.20 to -0.07). 2)The multivariable-adjusted relative risk (RR) indicated that increased selenium levels correlated with a significant reduction in the risk of ischemic stroke (RR = 0.88 [95% CI 0.83-0.92]).3)Furthermore, our meta-analysis found that higher circulating selenium was related with a decreased risk of stroke mortality, with an adjusted relative risk of 0.86 (95% CI 0.80, 0.93).Increased dietary selenium intake was inversely related to stroke risk, with an RR of 0.87(95% CI 0.76,0.99).4)A meta-analysis of dose-response curves revealed that circulating selenium levels were adversely linked with stroke.Conclusions:Higher circulating selenium and dietary selenium intake is correlated with a significantly induced incidence of ischemic stroke, meanwhile,a negative linear association was found between dietary selenium intake and stroke.
Keywords: lnutrition, Stroke, Selenium, Microelements, Antioxidants
Received: 08 Apr 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Li, Gao, Ding, Pei and Piao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lifeng Piao, piaolifeng2024@163.com
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