ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1583982
This article is part of the Research TopicGenetic Insights and Diagnostic Innovations in Cerebrovascular and Cerebrospinal Fluid DisordersView all 13 articles
Oligodendrocyte precursor cell transplantation attenuates inflammation after ischemic stroke in mice
Provisionally accepted
- 1Huadong Hospital, Fudan University, Shanghai, Shanghai Municipality, China
- 2Shanghai Jiao Tong University, Shanghai, Shanghai Municipality, China
- 3Zhongshan Hospital, Fudan University, Shanghai, Shanghai Municipality, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Disruption of blood-brain barrier and neuroinflammation are critical pathological features in the acute phase of ischemic stroke. This study investigates whether oligodendrocyte precursor cell transplantation can downregulate inflammation to attenuate blood-brain barrier disruption following ischemic brain injury.: Adult male Institute of Cancer Research mice (n=60) underwent transient middle cerebral artery occlusion. Post ischemic assault, these mice received a stereotactic injection of oligodendrocyte precursor cells (6×10 5 ). Neurobehavioral outcomes, infarct volume, inflammatory cytokines, myeloperoxidase, and tight junction protein levels were measured following ischemia. Results: Oligodendrocyte precursor cell transplantation reduced infarct volume, alleviated anxiety and depression, and promoted neurological recovery after ischemic stroke. Compared to the control group, oligodendrocyte precursor cell treated mice exhibited reduced levels of inflammatory cytokines IL-1, IL-6, and TNF-, reduced neutrophil infiltration, and diminished loss of tight junction protein. Oligodendrocyte precursor cells alleviated inflammation by increasing -catenin expression. The administration of -catenin inhibitor blocked the beneficial effects of oligodendrocyte precursor cell transplantation on neuroinflammation and blood-brain barrier permeability.This study demonstrates that oligodendrocyte precursor cell transplantation attenuates neuroinflammation and protectes blood-brain barrier in the acute phase of ischemic stroke. Our findings indicate that oligodendrocyte precursor cell transplantation is a promising therapeutic approach for ischemic stroke.
Keywords: Blood-Brain Barrier, Inflammation, ischemic stroke, oligodendrocyte precursor cell, transplantation Abbreviations
Received: 26 Feb 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Wang, Liu, Yuanyuan, Yan, Yang, Qu and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenshi Wei, Huadong Hospital, Fudan University, Shanghai, Shanghai Municipality, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.