SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Movement Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1589760
Global Trends of early-onset Parkinson's disease from 1990 to 2021, and projections until to 2030: a systematic analysis of the global burden of disease study 2021
Provisionally accepted
- 1Northern Theater Command General Hospital, Shenyang, China
- 2China Medical University, Shenyang, Liaoning Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
This study aims to evaluate the global, regional, and national trends in prevalence, incidence, mortality, and DALYs for early-onset Parkinson's disease (EOPD) from 1990 to 2021.Methods: All data from the Global Burden of Diseases (GBD) 2021 were stratified by age, sex, location, and sociodemographic index (SDI). We performed comprehensive analysis to reveal trends for EOPD, utilizing average annual percentage change (AAPC), Joinpoint regression analysis, health inequality analysis, frontier analysis, and Bayesian age-period-cohort (BAPC) models.
Keywords: Parkinson's disease, neurodegenerative disease, Global disease burden, Trends, Health inequality analysis
Received: 30 Mar 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 LI, Hu, Mao and LIANG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yunhui LI, Northern Theater Command General Hospital, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.