SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1595194
This article is part of the Research TopicInnovative Strategies in Overcoming Glioblastoma: Advancements in Treatment and ResearchView all 3 articles
Bibliometric and Visualization Analysis of Glioma Pharmacotherapy from 2020 to 2024
Provisionally accepted
Xinjie Hong1
Wei Zhentao1,2
Tian Zuo1Liyu Xu1,2Haohang Zhang1,2Tao Xu1Dongmei Wang1Chengyin Lu1
Lijun Hou1*- 1Department of Neurosurgery, Second Affiliated Hospital of Naval Medical University, Shanghai, China
- 2School of Basic Medical Sciences, Navy Medical University, shanghai, China
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Objective: Gliomas are the most common and aggressive malignant tumors of the central nervous system. Their complex biology and adaptive resistance mechanisms pose major obstacles to existing treatment strategies. This study aims to analyze research published over the past five years to identify emerging trends, effective therapeutic agents, and novel treatment strategies.Methods: Relevant articles on glioma drug therapy were retrieved from the Web of Science Core Collection for the period 2020-2024. Bibliometric analyses were performed using CiteSpace and VOSviewer to examine authorship, institutional and national contributions, journal impact, and keyword distributions. A total of 9,701 articles were included in the analysis.: China leads in publication volume on glioma research, followed by the United States. Liu Yang from China is the most prolific author in this field over the past five years. Institutions from China and the United States are the primary contributors to this area of research. Bibliometric analysis identified four major thematic clusters: glioma treatment, drug delivery, immunotherapy and the tumor microenvironment, and the molecular mechanisms underlying glioma cell behavior. Conclusion: This systematic analysis of glioma treatment research over the past five years highlights key global research hotspots and emerging trends. Drug delivery and immunotherapy have gained increasing attention as promising therapeutic approaches. Advances in glioma treatment are expected to improve patient outcomes.
Keywords: Glioma, Pharmacotherapy, bibliometric analysis, Research trends, treatment strategies
Received: 17 Mar 2025; Accepted: 26 May 2025.
Copyright: © 2025 Hong, Zhentao, Zuo, Xu, Zhang, Xu, Wang, Lu and Hou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lijun Hou, Department of Neurosurgery, Second Affiliated Hospital of Naval Medical University, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.