ORIGINAL RESEARCH article
Front. Neurol.
Sec. Pediatric Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1600185
Increased 25-Hydroxycholesterol as an indicator for patients with vestibular neuritis
Provisionally accepted
- Affiliated Hospital of Hebei University, Baoding, Hebei Province, China
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Background: Vestibular neuritis (VN) is one of the most common diseases in vestibular vertigo. was correlated to neuroinflammation, however, whether the level of serum 25-HC could be used to diagnose the VN occurrence remains unclear.The enrolled patients were divided into VN and healthy control groups.Afterwards, the potential risk factors were assessed in these two groups. Subsequently, the complete blood count was performed upon hospital admission.The serum 25-HC and C-reactive protein (CRP) were detected in two groups using liquid chromatography-mass spectrometry and a high-sensitive immunonephelometric assay. Moreover, the correlation of 25-HC to inflammatory factors was analyzed. Finally, the receiver operating characteristic curve analysis was performed to predict the diagnosis effect of 25-HC in VN occurrence. The age, gender, BMI, living habits, disease history, and cholesterol did not affect the VN occurrence.However, 25-HC was dramatically increased in VN patients, meanwhile, peripheral blood leukocyte and neutrophil/lymphocyte ratio were also elevated in VN patients.Importantly, 25-HC was positively correlated to CRP and leukocytes. Additionally, the level of serum 25-HC could be used to predict the VN occurrence.Conclusions: Serum 25-HC may diagnose the occurrence of VN.
Keywords: Vestibular Neuritis, 25-HC, crp, diagnosis, Inflammation
Received: 26 Mar 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Song, Liang and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Congzhe Tian, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China
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