ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1619727
Association between the atherogenic index of plasma and the non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with early neurological deterioration after thrombolysis
Provisionally accepted
- 1Department of neurology, Changsha Central Hospital, Changsha, China
- 2The Second People’s Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, China
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The atherogenic index of plasma (AIP) and non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) are newly developed markers of lipid and glucose metabolism. Nevertheless, the associations between the AIP or NHHR and early neurological deterioration (END) following thrombolysis in patients with acute ischemic stroke (AIS) remain ambiguous.: 1323 AIS patients who had intravenous thrombolysis between January 2018 and October 2024 were retrospectively analyzed. An increase in the National Institutes of Health Stroke Scale (NIHSS) score of > 4 within 24 hours following thrombolysis was considered post-thrombolysis END. Logistic regression analysis was conducted to investigate the associations between the AIP and NHHR with post-thrombolysis END. Receiver operating characteristic (ROC) analysis was employed to evaluate the AIP and NHHR capacity to differentiate post-thrombolysis END. Results: Of the 1323 patients who were recruited, 1125 (85.03%) had non-END and 198 (14.97%) had post-thrombolysis END. A binary logistic regression model demonstrated that the AIP (odds ratio [OR], 1.657; 95% confidence interval [CI] 1.441-1.875, P<0.001) and NHHR (OR, 1.519; 95% CI, 1.342-1.812, P< 0.001) were independent factors for post-thrombolysis END. The area under the curve (AUC) values for the AIP, NHHR, and AIP combined with the NHHR for post-thrombolysis END were 0.753, 0.678, and 0.795, respectively.Conclusions: Our study suggests that the AIP and NHHR could be used as prognostic indicators to predict post-thrombolysis END.
Keywords: Acute ischemic stroke, Atherogenic index of plasma, non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio, Early neurological deterioration, Lipid Metabolism, risk factor
Received: 28 Apr 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Li, Deng, Song, Wang, Xu, Feng, Chen, Wan and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fangyi Li, Department of neurology, Changsha Central Hospital, Changsha, China
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