REVIEW article
Front. Neurol.
Sec. Epilepsy
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1635441
This article is part of the Research TopicImpact of aging on small molecule transport across the blood-brain barrier in neurodegenerative disordersView all articles
Ferroptosis and Epilepsy: Bidirectional Pathogenic Links and Therapeutic Implications
Provisionally accepted
- 1Chinese People's Liberation Army Western Theater General Hospital, Chengdu, China
- 2Department of Neurosurgery, Western Theater General Hospital, Chengdu, Sichuan, China, Chengdu, China
- 3Department of Hyperbaric oxygen medicine，Western Theater General Hospital, Chengdu, Sichuan, China, chengdu, China
- 4Independent researcher, Chengdu, China
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Ferroptosis is a distinctive form of regulated cell death that is closely associated with various neurodegenerative disorders. In recent years, an increasing number of studies have demonstrated the crucial role of ferroptosis in the development and progression of epilepsy. Firstly, this article will review the existing research on the specific biological mechanism of ferroptosis in nerve injury, particularly in epilepsy, encompassing iron metabolism disorders and alterations in the expression of ferroptosis-related proteins. Secondly, with regards to treatment, this article will explore the application of ferroptosis inhibitors in antiepileptic therapy and their potential therapeutic effects. Additionally, it will focus on investigating the interaction between ferroptosis and existing antiepileptic drugs as well as the potential impact of strategies regulating ferroptosis on epilepsy treatment. Finally, we will evaluate both the progress made and limitations encountered in current research while proposing possible future directions for further exploration at the intersection of ferroptosis and epilepsy fields.These studies not only contribute to a better understanding of epileptic pathological mechanisms but also hold promise for providing novel insights and strategies for treating epilepsy.
Keywords: ferroptosis, Epilepsy, iron metabolism, Lipid Peroxidation, Reactive Oxygen Species
Received: 30 May 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Xu, Dong, Yuan, Chen, Shu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Haifeng Shu, Department of Neurosurgery, Western Theater General Hospital, Chengdu, Sichuan, China, Chengdu, China
Sixun Yu, Independent researcher, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.