ORIGINAL RESEARCH article
Front. Neurol.
Sec. Headache and Neurogenic Pain
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1650891
Association of Migraine with Depression, Anxiety, and Stress in the Population in Aseer Region: A Cross-Sectional Study Authors
Provisionally accepted
Amjad Khalid Y Abumilha1Abdullah Saeed A Abukaftah2Mohammed Mushabab Al-Mudhi3Nojoud Ali Al Fareh4
Abdulaziz Muflih Abudasser5*- 1Abha Mental Health Hospital, Abha, Saudi Arabia
- 2King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia
- 3General Directorate of Health Affairs in Aseer Region, Abha, Saudi Arabia
- 4King Khalid University College of Medicine, Abha, Saudi Arabia
- 5College of Medicine, King Khalid University, Abha, Saudi Arabia
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Aim: To measure the association between migraine and depression, anxiety and stress in Aseer region, Saudi Arabia.A cross-sectional study was conducted in the Aseer region, targeting residents aged 18 or older. The questionnaire's validity and reliability were assessed through a pilot study and expert review. The final questionnaire was distributed online to eligible participants.Results: A total of 395 eligible participants completed the study questionnaire.Participants ages ranged from 18 to more than 40 years with a mean age of 28.5 ± 12.1 years old. A total of 159 (40.3%) participants had symptomatic migraine. Migraine increased the likelihood for having depression by about 7 times (OR=7.1; 95% CI: 3.9-12.7) and increased the likelihood for anxiety disorder by about 8 times (OR=8.3; 95% CI: 4.4-15.6) and the likelihood for stress by about 5 times (OR=5.2; 95% CI: 3.1-8.3) adjusting for the effect of other personal characteristics.The study found that less than half of participants met migraine clinical criteria, resulting in high anxiety, depression, and stress rates, despite adjusting other participant characteristics.
Keywords: Migraine, Mental Disorders, Depression, stress, Saudi Arabia
Received: 20 Jun 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Abumilha, Abukaftah, Al-Mudhi, Al Fareh and Muflih Abudasser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Abdulaziz Muflih Abudasser, College of Medicine, King Khalid University, Abha, Saudi Arabia
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