ORIGINAL RESEARCH article
Front. Neurol.
Sec. Dementia and Neurodegenerative Diseases
A Comparative Analysis of Health-Related and Individual Quality of Life in People with Parkinson's Disease
Provisionally accepted
- Department of Neurology, University Hospital of Basel, Basel, Switzerland
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Quality of life (Qol) results from a complex interplay of physical, mental, and social aspects. Traditional assessments of Qol may not adequately describe well-being in serious chronic illness such as in people with Parkinson's disease (PwPD). This cross-sectional observational study explores differences and similarities of assessment through Health-Related Qol (HRQoL) versus individual Qol, measured as Schedule for the Evaluation of Individual Qol (SEIQoL), and analyzes the relative contributions of the most common psychological difficulties (anxiety, depression, apathy) in Parkinson's disease. 48 PwPD (mean age: 67 years; IQR: 60.25–72.75; 12 women) completed SEIQoL and Parkinson's Disease Questionnaires (PDQ-39) for HRQoL. In addition, measures for anxiety, depression, apathy, cognitive function, daytime sleepiness, and motor performance were obtained. Multiple linear regression was performed with both QoL summary indices as dependent variables. Interestingly, HRQoL and SEIQoL were not correlated to each other. Of all psychological difficulties only anxiety was a significant predictor of HRQoL and only self-rated apathy was a significant predictor of SEIQoL. High daytime sleepiness and medication doses were associated with lower HRQoL. In contrast, SEIQoL showed that family, relationships, autonomy and health were the most important domains, with health satisfaction being lowest. HRQoL and SEIQoL measure different aspects of QoL. Therefore, in future research studies both should be used together for an adequate assessment of therapies and effective rehabilitation strategies to ease the burden for PwPD.
Keywords: Health-related QOL, individual Qol, Schedule for the Evaluation of Individual Qol, SEIQoL, Anxiety, Depression, Apathy, Psychology
Received: 14 Aug 2025; Accepted: 30 Nov 2025.
Copyright: © 2025 Toloraia, Elsas, Tasci, Fuhr and Gschwandtner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ute Gschwandtner
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