ORIGINAL RESEARCH article
Front. Neurol.
Sec. Pediatric Neurology
High-Stimulation-Rate ABR Predicts Persistent Auditory Pathway Dysfunction in Neonates with Severe Hyperbilirubinemia: A 6-Month Longitudinal Study
Provisionally accepted
- 1川北医学院附属医院, 中国 四川 南充, China
- 2Longquanyi District Maternal and Child Health Hospital, 川北医学院附属医院, 中国 四川 南充, China
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This prospective longitudinal study demonstrates that high-stimulation-rate (51.1/s) auditory brainstem response (ABR) effectively detects and differentiates auditory pathway dysfunction in neonates with hyperbilirubinemia (NH). The severe NH group (TSB >320.6 μmol/L) showed significantly prolonged I-V interpeak latency differences (△IPL I-V) compared to both mild-to-moderate NH and healthy controls during initial hospitalization (P<0.05), with a strong positive correlation between peak TSB levels and △IPL I-V (r=0.712). While some recovery occurred by 3 months, severe NH infants maintained persistently abnormal △IPL I-V values at 6-month follow-up, unlike the mild-to-moderate group which showed transient alterations. These findings support incorporating high-stimulation-rate ABR into routine follow-up protocols for severe NH cases to identify persistent auditory pathway abnormalities requiring early intervention.
Keywords: auditory brainstem response, High stimulation rate, Hyperbilirubinemia, longitudinal study, neonates
Received: 17 Aug 2025; Accepted: 19 Dec 2025.
Copyright: © 2025 Qing-chun, lI, Pei and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pan Qing-chun
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