ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
This article is part of the Research TopicChronic Large-Vessel Occlusion in Cerebrovascular Disease: Pathophysiology, Diagnosis, and Therapeutic AdvancesView all articles
The Impact of Low Plasma Atherosclerosis Index on Hemorrhagic Transformation After Endovascular Treatment of large artery atherosclerotic Stroke
Provisionally accepted
Jianqiang Hu1
Cheng Mingqing1
Shuyu Ma1
Jiawei Zhang1Xin Miao1Tingting Liu2
Kefangyuan Zheng1Yalan Fang3*
Jin Zhang2- 1Shanxi Medical University, Taiyuan, China
- 2First Hospital of Shanxi Medical University, Taiyuan, China
- 3Second Hospital of Shanxi Medical University, Taiyuan, China
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Objective: The plasma Atherosclerosis Index (AIP) reflects lipid metabolism, but its relationship with hemorrhagic transformation (HT) after endovascular treatment (EVT) in large artery atherosclerotic stroke (LAA) is unclear. This study aims to assess AIP's potential in predicting HT occurrence. Methods: This retrospective study analyzed 467 LAA patients. The patients were grouped based on infarct volume (small, moderate, and large). Univariate and multivariate logistic regression models evaluated the relationship between AIP levels and HT risk. Additionally, we analyzed hemorrhagic infarction (HI), parenchymal hemorrhage (PH) and symptomatic hemorrhagic transformation (sHT) to evaluate the relationship between AIP and the risk of them. Results: Among the 467 patients, 199 experienced HT after EVT. After adjusting for confounders in the multivariate logistic regression model, lower AIP (OR=0.20, P=0.001) was significantly associated with an increased risk of HT. Subgroup analysis revealed that in the small infarct volume group, lower AIP (OR=0.11, P=0.012) was significantly associated with the risk of HT. AIP was also This is a provisional file, not the final typeset article significantly associated with the risk of HI (OR=0.12, P=0.003) and sHT(OR=0.11, P=0.002) in HT. Conclusion: Lower AIP levels are an independent risk factor for HT after EVT in LAA patients, especially in the small infarct volume group. Moreover, AIP is associated with HI and sHT.
Keywords: The atherogenic index of plasma, endovascular treatment, Hemorrhagic transformation, infarct volume, large-artery atherosclerotic stroke
Received: 28 Aug 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Hu, Mingqing, Ma, Zhang, Miao, Liu, Zheng, Fang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yalan Fang, fangyalan.2008@163.com
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