REVIEW article
Front. Neurol.
Sec. Stroke
This article is part of the Research TopicMicroglial Responses to Intracranial HemorrhageView all 3 articles
Emerging roles for Interleukin-11 in the Inflammatory Response of Intracerebral Hemorrhage
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2Hangzhou First People's Hospital, Hangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Intracerebral hemorrhage (ICH) is a severe cerebrovascular disorder with high rates of disability and mortality. Secondary inflammatory responses are recognized as pivotal determinants of patient outcomes and neurological recovery. In recent years, interleukin-11 (IL11), an important member of the IL6 cytokine family, has attracted increasing attention for its role in various inflammatory diseases and neurological injuries. Emerging evidence indicates that IL11 expression undergoes significant alterations following ICH and participates in regulating immune cell activation, cytokine secretion, and blood–brain barrier integrity. Beyond its complex interactions with other inflammatory mediators, IL11 may also exert neuroprotective effects, thereby providing a novel theoretical basis for therapeutic interventions targeting post-ICH inflammation. This review systematically summarizes the expression dynamics, molecular mechanisms, and potential therapeutic implications of IL11 in the context of ICH-associated inflammation, with the aim of offering new insights into strategies for modulating inflammatory responses in ICH patients.
Keywords: intracerebral hemorrhage, IL11, Inflammatory Response, cytokine, Neuroprotection
Received: 05 Oct 2025; Accepted: 08 Dec 2025.
Copyright: © 2025 Xue, Zhu, Wang, Wang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenhua Yu
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.