Horizontal Head-Shaking Test: Pathophysiological Mechanisms and Clinical Interpretation

Vincenzo Marcelli¹Beatrice Giannoni²Giampiero Volpe³Michele Cavaliere⁴Edoardo Marcelli⁵Mario Faralli⁶ANNA RITA FETONI^1*Vito Enrico Pettorossi⁷

• ¹Department of Neuroscience, Reproductive Science and Dentistry, Section of Audiology, University of Naples “Federico II”, Naples, Italy, Napoli, Italy
• ²Department of Neuroscience, Psychology, Drug’s Area and Child’s Health, University of Florence, Florence, Italy,, Florence, Italy
• ³Department of Neurology, Ospedale San Luca di Vallo della Lucania, ASL Salerno, Salerno, Italy, Vallo della Lucania, Italy
• ⁴Department of Neuroscience, Reproductive Science and Dentistry, Section of Audiology, University of Naples “Federico II”, Naples, Italy,, Napoli, Italy
• ⁵Faculty of Medicine and Surgery, University of Salerno, Salerno, Italy, Salerno, Italy
• ⁶Department of ENT, University of Perugia, Perugia, Italy, Perugia, Italy
• ⁷Department of Medicine and Surgery, University of Perugia, Perugia, Italy, Perugia, Italy

The horizontal Head-Shaking Test (HST) is a simple, rapid, and non-invasive bedside maneuver that provides valuable insights into both peripheral and central vestibular function. Originally described in the late 19th century and standardized in the 1970s, the HST predominantly stimulates the lateral semicircular canals (LSCs) at high frequencies. Its diagnostic power lies in revealing dynamic asymmetries of the angular vestibulo-ocular reflex (aVOR) and uncovering central abnormalities involving the brainstem and, above all, cerebellum. The pathophysiological basis of post-head-shaking nystagmus (post-HSN) derives from Ewald’s second law, which explains the excitatory–inhibitory imbalance between the labyrinths, further processed through the Velocity Storage mechanism (VSM). The VSM extends and integrates canal signals, aligning them with gravity through the action of the cerebellar nodulus and ventral uvula. Its modulation determines the direction, duration, and morphology of post-HSN, accounting for central features such as perverted or minimal-stimulus responses. The VSM is furthermore crucial for higher-order functions such as motion perception, spatial orientation, and postural stability. Clinically, the HST contributes to discrimination between peripheral lesions—typically producing monophasic or biphasic horizontal post-HSN—and central disorders, which yield vertical or torsional (perverted) responses, or exaggerated responses due to cerebellar disinhibition. Thus, rather than an empirical test, the HST represents a neurophysiologically grounded tool that bridges bedside observation and the vestibular integration. When interpreted within a comprehensive clinical framework, it offers diagnostic, prognostic, and educational value, serving as a window into the physiology and pathology of vestibular–cerebellar networks.