Intervention effects of different brands of botulinum toxin type A in Meige syndrome with anxiety symptoms

Yunyu TangRuen Liu^*

• Peking University People's Hospital, Beijing, China

Background: Patients with Meige syndrome are often affected by anxiety symptoms, and drug therapy is the main treatment option, of which botulinum toxin A is the more frequently used drug. This paper analyzes the intervention effect of different brands of botulinum toxin A on Meige syndrome with anxiety symptoms, which is expected to provide theoretical basis for the rational selection of clinical treatment options. Methods: A retrospective analysis was conducted on 148 patients treated between January 2021 and December 2023. Patients were divided into two groups based on the BoNT-A brand received: the Chinese botulinum toxin type A (Hengli) group (n=80) and the onabotulinumtoxinA (Botox) group (n=68). Both groups received local injections at muscle spasm sites. Outcomes included spasm relief degree, duration of efficacy, scores on the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS), polysomnography parameters [Sleep Efficiency (SE), Total Sleep Time (TST), Sleep Latency (SL), Number of Wakefulnesses (AI), Rapid Eye Movement Sleep time (REMS)], and adverse reactions. Results: There was no statistically significant difference in the comparison of total remission rate and efficacy maintenance time between the two groups (P > 0.05). The differences in the grades of SAS, SDS, SE, TST, SL, AI, and REMS before and after treatment between the two groups were not statistically significant when compared (P > 0.05). There was no statistically significant difference between the two groups when comparing the incidence of adverse reactions such as incomplete eyelid closure, facial muscle weakness, and drooping of the corners of the mouth during expression muscle activity (P > 0.05). Conclusion: Local injection of botulinum toxin type A is safe and effective for Meige syndrome with anxiety symptoms, and there is no significant difference in the efficacy, duration of action, and improvement of psychological state and sleep quality between different brands of botulinum toxin type A. Clinical practice should be based on practical considerations and then reasonably select the appropriate brand of botulinum toxin type A for treatment.