BRIEF RESEARCH REPORT article
Front. Neurol.
Sec. Dementia and Neurodegenerative Diseases
Swallowing Characteristics in Down Syndrome at an Advanced Age: A Preclinical Study in the Ts65Dn Mouse Model
Provisionally accepted
- 1University of Wisconsin-Madison, Department of Otolaryngology, Madison, United States
- 2Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, United States
- 3The Children’s Guild Foundation Down Syndrome Research Program, Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, United States
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Down syndrome (DS) occurs in approximately one in 800 births worldwide and is associated with various medical complications including swallowing impairments and dysphagia. Advances in childhood survival have led to an increased number of people with DS reaching older ages. Aging is generally accompanied by changes in sensory and motor functions, including those involved in swallowing. Swallowing impairments can lead to complications such as malnutrition, dehydration, and aspiration pneumonia. Despite the multifactorial nature of swallowing impairments in older people with DS, research in this area remains limited, with most studies focusing on pediatric populations. We hypothesized that aged Ts65Dn mice (mouse model of DS; 14 males, 15 females) would demonstrate significant impairments in swallowing performance on quantitative measures derived from videofluoroscopic swallow studies, relative to age-matched euploid controls (genetically typical mice; 14 males and 15 females). Statistical analyses included two-way ANOVA for genotype and sex effects. The Ts65Dn group exhibited significantly lower swallow rates, longer inter-swallow intervals (ISI), increased jaw cycle: swallow ratios (JSR), and lower jaw excursion rates (JER) than euploid controls. Body weight was significantly lower in the Ts65Dn group. These findings confirm persistent swallowing impairments in aged Ts65Dn mice, supporting their use as a model for studying swallowing mechanisms, provide critical insights into swallowing impairments in aging DS and support the need for specialized clinical interventions for swallowing disorders in this population.
Keywords: Aging, Down Syndrome, Mouse, swallowing, VFSS
Received: 17 Sep 2025; Accepted: 04 Jan 2026.
Copyright: © 2026 Ostadi, Fisher, Yu, Connor and Glass. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tiffany J Glass
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