SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Dementia and Neurodegenerative Diseases
A bibliometric analysis of alpha-synuclein in Parkinson's disease from 2015 to 2024
Liangman Xiao 1,2
LIN ShuMin 2
Yixuan Wu 2
Xin Liu 2
Danxia Gu 2
Fan Jingqi 3
Lixing Zhuang 3
1. Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
2. Guangzhou University of Chinese Medicine, Guangzhou, China
3. First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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Abstract
Objective: This study employs bibliometric analysis to systematically examine global research trends and map the intellectual landscape of α-synuclein (α-syn) in Parkinson's disease (PD) from 2015 to 2024. Methods: On January 14, 2025, bibliographic data were extracted from the Web of Science Core Collection (WOSCC) and PubMed. Using CiteSpace (version 6.2.R4), VOSviewer (version 1.6.20), the Bibliometrix R package (4.4.2), and Microsoft Excel 2024, we analyzed publication trends, geographic and institutional contributions, journal distributions, author distributions, co-cited references, and keyword co-occurrences. Results: A total of 10,390 publications were included, with a steady annual growth (R² = 0.8741). The United States, China, and Germany were the top contributing countries. Leading institutions included the University of Cambridge and the University of Pennsylvania. Core journals such as Movement Disorders and International Journal of Molecular Sciences exhibited significant influence. Keyword clustering highlighted research hotspots, including neurodegeneration, aggregation, oxidative stress, Lewy bodies, and emerging diagnostic technologies like RT-QuIC. Important trends were identified in immune mechanisms, exosome-mediated propagation, gut-brain axis involvement, and cross-disease mechanisms. Conclusion: The significance of α-syn in Parkinson's disease research is growing. Future efforts should emphasize mechanistic studies, biomarker validation, and targeted therapies to advance personalized medicine in PD.
Summary
Keywords
alpha-Synuclein, Bibliometrics, Parkinson's disease, PubMed, Web of Science Core Collection
Received
24 September 2025
Accepted
19 February 2026
Copyright
© 2026 Xiao, ShuMin, Wu, Liu, Gu, Jingqi and Zhuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Lixing Zhuang
Disclaimer
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