ORIGINAL RESEARCH article
Front. Neurol.
Sec. Sleep Disorders
This article is part of the Research TopicData-Driven Brain Imaging and Signal Analysis: Methods from Acquisition to Clinical InsightView all 4 articles
Brain microstructural alterations and cognitive impairment in obstructive sleep apnea: A diffusion kurtosis imaging study
Provisionally accepted
- 1The Sixth Hospital of Shanxi Medical University，General Hospital of TISCO, 030001, Taiyuan, China
- 2Shanxi Medical University, Taiyuan, China
- 3GE Healthcare China Co Ltd, Beijing, China
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Background: This study aimed to investigate brain microstructural alterations and their association with neurocognitive impairment in adults with moderate to severe obstructive sleep apnea (OSA) using diffusion kurtosis imaging (DKI), to better understand the neuropathological mechanisms contributing to cognitive decline in OSA. Materials and methods: 40 OSA patients and 40 matched healthy controls underwent cognitive assessments using the Montreal Cognitive Assessment (MoCA) and MRI scans including DKI and 3D T1-weighted imaging. DKI were processed to generate kurtosis parameter maps, including axial kurtosis (AK) and radial kurtosis (RK). Brain region values were extracted using SPM12. Group comparisons were conducted for cognitive scores and kurtosis values. Receiver operating characteristic (ROC) curves were used to assess the diagnostic performance of imaging biomarkers. Partial correlation analysis examined relationships between imaging metrics, cognitive scores, and sleep-related variables. Multiple comparisons were corrected using the false discovery rate (FDR) method. Results: The OSA group showed increased AK in 9 brain regions and decreased RK in 28 regions. MoCA scores, particularly in visual space and executive function, abstraction, and delayed recall, were significantly lower in the OSA group. ROC analysis showed that RK in specific brain regions had strong diagnostic accuracy for OSA (AUC = 0.817). Lower oxygen saturation (LSpO2) was associated with altered kurtosis values in key regions related to cognition. Cognitive scores were positively correlated with RK values in regions such as the frontal cortex, cingulate cortex, and hippocampus. Conclusions: DKI effectively detects microstructural brain changes in OSA patients. These alterations are associated with cognitive decline, providing valuable insights into the potential mechanisms underlying neurocognitive impairments in OSA.
Keywords: Axial kurtosis, Cognitive Function, diffusion kurtosis imaging, obstructive sleep apnea, radial kurtosis
Received: 18 Dec 2025; Accepted: 02 Feb 2026.
Copyright: © 2026 Zhang, He, Guo, Xiao, Li and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kun Peng
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