ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
This article is part of the Research TopicPersonalized Medicine in Cerebrovascular Disease: From Precision Diagnostics to Tailored TherapiesView all 3 articles
Aneurysmal Subarachnoid Hemorrhage (aSAH)-Risk Score – Impact of Pre-existing Cardiovascular Risk Factors on Functional Patient Outcomes
Provisionally accepted
Helen Ritter1Dirk Halama2Felix Arlt3Anika Stockert4Robert Werdehausen5
Karl-Titus Hoffmann6
Cindy Richter6*- 1Universitat Leipzig Medizinische Fakultat, Leipzig, Germany
- 2Mund-, Kiefer-, Gesichtschirurgie, Universitatsklinikum Leipzig, Leipzig, Germany
- 3Neurochirurgie, Universitatsklinikum Leipzig, Leipzig, Germany
- 4Neurologie, Universitatsklinikum Leipzig, Leipzig, Germany
- 5Anästhesie und Intensivmedizin, Universitatsklinikum Magdeburg, Magdeburg, Germany
- 6Institut für Neuroradiologie, Universitätsklinikum Leipzig, Leipzig, Germany
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Background: Predictive tools for assessing outcomes after aneurysmal subarachnoid hemorrhage (aSAH) are limited, particularly with respect to long-term functional outcome. Reliable risk stratification in the early course of aSAH is crucial for determining optimal patient management, effective use of clinical resources, and ultimately improving patient outcomes. This study aimed to design a prognostic score based on retrospectively collected clinical variables to predict functional outcome or delayed cerebral ischemia as primary endpoints in patients with aSAH. Methods: Between January 2014 and March 2022, 386 patients with aSAH were admitted to our hospital. Two hundred thirty of these patients were included in our study. Seventeen clinical, radiological, and demographic variables were analyzed using the chi-squared test and logistic regression to identify significant predictors of an unfavorable outcome (mRS 4-6) after 6 months or DCI development. A nomogram defined the weighting of each factor within a newly developed aSAH-Risk score. Results: Significant risk factors were identified to predict functional outcome. Of these, five variables were included to create the aSAH-Risk score with a maximum of 13 points: arterial hypertension (p=0.001, no=0, yes=2), intracranial vasosclerosis (p = 0.0002, none=0, yes=2), modified Fisher scale (p <0.001, scale 1=0, scale 3=2, scale 2 or 4=3), intracerebral hemorrhage (no=1, yes=2) and World Federation of Neursosurgical Societies grading (p <0.001, 1=0, 2=1, 3 or 4=3, 5=4). Forty percent was the minimal calculated risk of an unfavorable outcome for an aSAH patient, increasing to 80% with an aSAH-Risk score of 13 points. An external cohort is required to validate the proposed score for general applicability. Conclusion: The aSAH-Risk score is a novel clinical tool to identify patients in need of long-term daily life assistance at admission.
Keywords: aneurysmal subarachnoid Hemorrhage, Cardiovascular risk-factors, functional outcome, Prediction model, risk score
Received: 05 Jan 2026; Accepted: 16 Feb 2026.
Copyright: © 2026 Ritter, Halama, Arlt, Stockert, Werdehausen, Hoffmann and Richter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Cindy Richter
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