ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Brain Imaging Methods
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1554287
A Surface-Based cross-sectional fMRI study on brain function differences between comorbid mild or moderate depression and insomnia
Provisionally accepted
Zhongxian Li1
Limei Chen1
Yingxin Huang1
Luda Yan1
Junquan Liang1Min Peng1
Yifu Zhou1
Jiliang Fang2Mengyao Li1
Zhou Peng1*- 1Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- 2Department of Radiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The mechanisms of Comorbid mild or moderate depression and insomnia (CmiDaI or CmoDaI ) are complex, and stratification remains poorly understood. Resting-state fMRI data were collected from 32 patients with CmiDaI, 32 with CmoDaI, and 30 healthy controls (HCs). Data were analyzed using a surface-based computational method to examine differences in amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) across the brain. Significant ALFF differences were found in the left dorsolateral prefrontal cortex (DLPFC) between CmiDaI and CmoDaI. Compared to CmoDaI, CmiDaI showed increased ALFF in the left DLPFC, decreased FC between left DLPFC and right superior temporal gyrus, and increased FC in the right supramarginal gyrus (SMG) and right inferior frontal gyrus (IFG).Correlation analysis suggests lower left DLPFC ALFF correlated with more severe depression and insomnia. Lower FC between left DLPFC and right IFG was associated with more severe depression, while lower FC between left DLPFC and right SMG correlated with more severe insomnia. Our findings suggest that reduced ALFF in the left DLPFC may serve as the potential biomarker to distinguish CmiDaI from CmoDaI, and offer insights for the two disorders' treatments.
Keywords: Surface-based study, Depression, insomnia, comorbid depression and insomnia, brain function Differences, functional magnetic resonance imaging (fMRI)
Received: 01 Jan 2025; Accepted: 21 Apr 2025.
Copyright: © 2025 Li, Chen, Huang, Yan, Liang, Peng, Zhou, Fang, Li and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhou Peng, Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.