Music-induced cognitive change and whole-brain network flexibility: A pilot study

E-Lim Lydia Wu-Chung^1*Melia E Bonomo²Anthony K Brandt²Bryan T Denny²Christof Karmonik³J. Todd Frazier⁴Karl Blench²Christopher Fagundes²

• ¹University of Pittsburgh, Pittsburgh, Pennsylvania, United States
• ²Rice University, Houston, United States
• ³Houston Methodist Research Institute, Houston, Texas, United States
• ⁴Houston Methodist Hospital, Houston, Texas, United States

Cognitive impairment that exceeds age-related cognitive decline is a risk factor for Alzheimer's disease and related dementias. As the older adult population is notably increasing every year, significant efforts are being made to preserve cognitive function in older adulthood. Non-pharmaceutical approaches such as music interventions have noticeable benefits for cognition. Music engagement utilizes multiple brain regions dually involved in higher cognitive functions. Yet the neurobiology of music-induced cognitive change remains understudied. Complex human behavior and cognition likely depend on continuous communication across brain regions rather than localized activity in one region. Given that music creativity engages a wide range of mental processes, whole-brain network indices quantifying the brain's tendency to create functional communities (modularity) and then dynamically reorganize these communities (flexibility) may be relevant for assessing music-related cognitive change. Using a semirandomized clinical trial design (ClinicalTrials.gov; NCT04137913), we examined whether 1) music creativity altered whole-brain network indices (modularity, flexibility) and 2) whether music-related effects on cognition depended on whole-brain network indices. Fifty-two older adults (Mean age = 75 yrs; 54% female; 84% White) were randomized to a 6-week music creativity intervention (n=25) or a no-treatment control condition (n=27) and completed resting-state fMRI scans and the Montreal Cognitive Assessment at baseline and follow-up (post-intervention). The music creativity intervention did not alter network flexibility or modularity over time. However, the relationship between group assignment and change in global cognitive function depended on baseline flexibility: music creativity improved global cognition more than the control condition, only among individuals who had higher than average network flexibility. Findings suggest that having a dynamic brain network, which has previously been linked to better executive functioning performance, may be necessary for music-related benefits on cognition. This pilot study is innovative as it is among the first to identify possible neural mechanisms underlying why music creativity interventions confer a more significant cognitive benefit for some older adults than others.