ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Translational Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1577059
This article is part of the Research TopicNon-invasive brain stimulation for chronic pain managementView all 5 articles
EVOLUTION OF SPINAL EVOKED COMPOUND ACTION POTENTIAL THRESHOLDS, VISUAL MOTOR THRESHOLDS, AND IMPEDANCES IN A RODENT SPARED NERVE INJURY MODEL
Provisionally accepted
David L Cedeño1,2Ricardo Vallejo1,2David C Platt1,2Joseph M Williams1
Leonid Litvak3
DAVID DINSMOOR3
Malgorzata Straka3*- 1Illinois Wesleyan University, Bloomington, Indiana, United States
- 2SGX Medical LLC, Bloomington, IL, United States
- 3Medtronic (United States), Minneapolis, United States
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The mechanisms of spinal cord stimulation (SCS) on neuropathic pain are commonly studied using the spared nerve injury (SNI) model, with stimulation amplitudes typically programmed relative to the visual motor threshold (vMT). Recent work explored the relationship between vMTs and spinal evoked compound action potential thresholds (ECAPTs)—a sensed measure of neural activation—in SNI rodents to better translate towards clinical dosing. However, changes across chronic healing beyond two days and pain states is unknown. This study tracked ECAPs through a traditional SNI-SCS approach, where nine rats were implanted with an SCS lead to evaluate effects of acute healing (days 0 to 1), chronic healing (days 1 to 7), nerve injury (days 7 to 14), and continuous SCS (days 14 to 16) using differential target multiplexed programming (DTMP). ECAPT:vMT ratios significantly increased on subsequent recordings from day 0 through day 14 (i.e., post-injury), but not between days 14 and 16 (after SCS), across anesthesia states, or SCS pulse widths. On average, ECAPT:vMT increased from 35 ± 2% (mean ± S.E.) on implantation day to 54 ± 1% on day 16. Future studies may use this approach to further elucidate the effects of chronic pain and SCS on the spinal ECAP.
Keywords: Evoked Potentials, Motor threshold (MT), Neuropathic pain (NP), rat model, ECAPS
Received: 14 Feb 2025; Accepted: 30 May 2025.
Copyright: © 2025 Cedeño, Vallejo, Platt, Williams, Litvak, DINSMOOR and Straka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Malgorzata Straka, Medtronic (United States), Minneapolis, United States
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