REVIEW article
Front. Neurosci.
Sec. Neuroendocrine Science
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1582743
This article is part of the Research TopicAdvances of lipid metabolism in neurological diseases and mental disordersView all 8 articles
Association between circulating plasma CTRP3 levels and acute ischemic stroke: a systematic review and meta-analysis
Provisionally accepted
- West China Hospital, Sichuan University, Chengdu, China
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Background: C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a novel adipokine that has been shown to exert neuroprotective effects in acute cerebral infarction. However, conflicting results have emerged regarding the circulating levels of CTRP3 between patients with acute ischemic stroke and healthy individuals. This meta-analysis aims to investigate the association between circulating CTRP3 levels and acute ischemic stroke. Objective: The objective of this meta-analysis is to re-evaluate the relationship between circulating CTRP3 levels and acute ischemic stroke. Methods: We conducted a comprehensive search across PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, Wanfang Data, and CBM to identify relevant studies up to February 2025 and 110 articles were found. After screening the titles, abstracts, and full texts, a total of 14 articles were ultimately included in this meta-analysis. Due to high heterogeneity, we conducted subgroup analyses stratified by patient characteristics, clinical and biochemical parameters, carotid intima-media thickness, IL-6 levels, CTRP9 levels, smoking, hypertension, and diabetes. Publication bias was evaluated using Egger's regression test, Begg's correlation analysis, and funnel plot visualizations. Results: The results indicated that patients with acute ischemic stroke exhibited significantly lower circulating levels of CTRP3 compared with control group (Z = 6.04, P < 0.00001). Subgroup analysis revealed that the observed heterogeneity could be attributed to patient age and body mass index (BMI). The year of publication, clinical biochemical parameters, carotid intimamedia thickness, IL-6, CTRP9, smoking, hypertension, and diabetes categorization were not sources of heterogeneity.The meta-analysis confirmed that circulating levels of CTRP3 were significantly lower in patients with acute ischemic stroke compared with control group. This association may be modulated by patient age and BMI.
Keywords: CTRP3, ischemic stroke, Meta-analysis, Adipokine, biomarker
Received: 24 Feb 2025; Accepted: 23 May 2025.
Copyright: © 2025 Niu, Zhu, Jiang and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yaowen Jiang, West China Hospital, Sichuan University, Chengdu, China
Zhi Wan, West China Hospital, Sichuan University, Chengdu, China
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