REVIEW article
Front. Neurosci.
Sec. Translational Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1585340
This article is part of the Research TopicCerebrovasculature in Focus: bridging the gap between mental health and illnessView all 4 articles
Development of perivascular astrocyte processes
Provisionally accepted
- CNRS UMR 7241 / INSERM U1050, INSERM U1050 Centre Interdisciplinaire de Recherche en Biologie, Paris, France
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Astrocytes are key glial cells in the brain that form specialized contacts with the vascular system. Together, these interactions constitute the gliovascular unit (GVU), which is an interface between the brain and the blood crucial for the maintenance of the structure and functions of the brain. The development of the GVU is a complex process involving multiple steps and intricate interactions among astrocytes, neural cells, and vascular components. In this review, we aim to summarize the current understanding of the development of the astrocyte–vascular interface and to explore how early developmental alterations in this system may contribute to brain dysfunction.
Keywords: Astrocytes, Blood Vessels, perivascular astrocyte processes, Endfeet, Gliovascular unit, neurovascular unit, Brain, brain interface
Received: 28 Feb 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Cohen-salmon, Guille and Boulay. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Martine Cohen-salmon, CNRS UMR 7241 / INSERM U1050, INSERM U1050 Centre Interdisciplinaire de Recherche en Biologie, Paris, 75005, France
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.