REVIEW article
Front. Neurosci.
Sec. Gut-Brain Axis
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1587818
This article is part of the Research TopicStrain-Specific Probiotics: Enhancing Children's Health Through Targeted Clinical ResearchView all 13 articles
Gut Microbiota and Autism Spectrum Disorder: Advances in Dietary Intervention Strategies Based on the Microbiota-Gut-Brain Axis Mechanism
Provisionally accepted
- 1School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
- 2Chengdu Women and Children’s Central Hospital, Chengdu, Sichuan Province, China
- 3Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China
- 4People’s Hospital of Deyang City, Deyang, Sichuan Province, China
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Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder that is primarily characterized by deficits in social interaction, impaired communication, restricted interests, and repetitive behaviors.The prevalence of ASD has been steadily increasing, establishing it as one of the leading causes of disability among children worldwide.Although the precise pathogenesis of ASD remains unclear, factors such as genetic predisposition, environmental exposures, immune dysregulation, and neurodevelopmental abnormalities are collectively believed to contribute to its onset.In recent years, the gut microbiota has emerged as a promising area of research in neurobiology, particularly in relation to advances in understanding the microbiota-gut-brain axis (MGBA) mechanism. Studies have shown that children with ASD exhibit significant dysbiosis in their gut microbiota, which may affect brain function via the MGBA,ultimately leading to abnormal behaviors and impaired emotional regulation.This review summarizes the role of the gut microbiota in the pathogenesis of ASD, examining how alterations in gut permeability, dysregulated
Keywords: Autism Spectrum Disorder, gut-brain axis, Gut Microbiota, Dietary intervention strategies, Microbiota-Metabolism Axis
Received: 06 Mar 2025; Accepted: 09 May 2025.
Copyright: © 2025 Fang, Zhou, Chen, Wang, Liu and Jia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ke Chen, Chengdu Women and Children’s Central Hospital, Chengdu, Sichuan Province, China
Ping Jia, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 611731, Sichuan Province, China
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