CASE REPORT article
Front. Neurosci.
Sec. Autonomic Neuroscience
This article is part of the Research TopicNew insights into stellate ganglion blockade in basic and clinical studiesView all 4 articles
Case Report: Celiac Plexus Block Improves Gastrointestinal Long Covid Symptoms
Provisionally accepted
Luke D Liu1*
Deborah Duricka1,2- 1Neuroversion Inc., Anchorage, Alaska, United States
- 2WWAMI School of Medical Education, Anchorage, United States
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Lingering symptoms following SARS-CoV-2 infection, recognized as the clinical entity "Long COVID", are common. Gastrointestinal dysfunction during and after COVID have received little attention to date and remain largely unaddressed. We have previously shown that numerous symptoms of Long COVID excluding gastrointestinal symptoms improve or resolve following stellate ganglion blocks (SGB). Here, we are first to report successful treatment of persistent post-COVID epigastric pain and diarrhea in three patients using celiac plexus block, a procedure commonly used for visceral abdominal pain and implicating the autonomic nervous system in Long COVID-associated GI symptoms.
Keywords: Long Covid, Irritable bowel syndrome (IBS), Gastrointestinal (GI) dysfunction, Visceral hyperalgesia, Diarrhea, Constipation, Stellate ganglion block (SGB), celiac plexus block (CPB)
Received: 08 Mar 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Liu and Duricka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Luke D Liu, lliu@neuroversion.net
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.