MINI REVIEW article
Front. Neurosci.
Sec. Gut-Brain Axis
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1594179
This article is part of the Research TopicImmune-gut-brain axis - A Key Player in Overall Human PathologiesView all 4 articles
Gut Microbiota and Stress Ulcers: Unraveling the Neurotransmitter Connection
Provisionally accepted
- Mutah University, Al Karak, Jordan
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Background Neurotransmitters are key signaling molecules in the brain-gut axis, may be involved in stress-induced ulcer damage. Objective This study aims to address the relationship between gut microbiota and the stress response is examined in this review, with a focus on how neurotransmitters moderate the impact of stress on mucosal integrity and gut health. Understanding these mechanisms may open new avenues for therapeutic interventions targeting the brain-gut axis. Methods A literature search was completed using PubMed, Web of Science, Cochrane, PsycINFO, Scopus and Embase databases for clinical and preclinical studies related to stress ulcer, gut microbiota and gut brain axis that published in English until November 2024.The gut microbiota plays important role in preserving the health of the digestive system and influencing the body's stress response through various pathways, including the enteric and autonomic nervous systems. This results in the production of microbial metabolites such as bile acids, tryptophan, and short-chain fatty acids that enter the bloodstream and go to the brain. Microbial neurotransmitters change the brain's gastrointestinal axis.The connection between stress ulcer, neurotransmitters, and the gut microbiota was outlined in this review.
Keywords: Stress ulcer, Microbiota-Brain-Gut axis, neurotransmitters, SCFAs, Glutamate
Received: 15 Mar 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Abdel-sater. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Khaled Abdel-sater, Mutah University, Al Karak, Jordan
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