ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Auditory Cognitive Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1600665
This article is part of the Research TopicMeniere’s Disease: From Diagnosis to TreatmentView all 11 articles
Optimizing Staging of Meniere's Disease: Integrating Electrocochleography with
Provisionally accepted
- 1The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- 2The Second People’s Hospital of Foshan, Foshan, China
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This study aimed to evaluate the diagnostic and staging efficacy of integrating electrocochleography (ECochG) with vestibular function tests-specifically cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP), caloric tests (CT), and video head impulse tests (vHIT)-for Meniere's disease (MD).Data were collected from 54 MD patients (66 affected ears) admitted to a hospital between January 2023 and January 2024. Each participant underwent pure tone audiometry, ECochG, cVEMP, oVEMP, CT, and vHIT. The results were compared against both established clinical criteria and a newly proposed staging system. Inclusion criteria followed the 2015 diagnostic guidelines for MD. Statistical analyses, including ANOVA, chi-square, and Kruskal-Wallis H tests, were conducted, and a random forest model was employed to validate the robustness of the proposed staging system.The novel staging system, incorporating vestibular function tests, demonstrated superior sensitivity and diagnostic accuracy compared to traditional audiometry-based staging. Early-stage MD detection improved significantly, with vestibular test abnormalities strongly correlating with disease progression. The overall positive rate for any test was 98.5%. ECochG abnormalities were detected in 54.5% of cases, while cVEMP and oVEMP abnormalities were observed in 75.8% and 69.7% of cases, respectively. The new staging system exhibited a stronger correlation with vestibular dysfunction, effectively identifying functional impairment prior to significant hearing loss.The integration of ECochG with vestibular function tests provides a more comprehensive diagnostic framework for MD. This multimodal approach enhances early detection, improves staging accuracy, and offers deeper insights into disease progression, thereby facilitating more personalized treatment strategies.
Keywords: Meniere's disease, Electrocochleography, Vestibular Function Tests, diagnostic staging, Inner ear dysfunction
Received: 26 Mar 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Huang, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xianren Wang, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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