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ORIGINAL RESEARCH article

Front. Neurosci.

Sec. Brain Imaging Methods

Volume 19 - 2025 | doi: 10.3389/fnins.2025.1610657

This article is part of the Research TopicImaging Brain Network and Brain Energy Metabolism Impairments in Brain DisordersView all 7 articles

Brain Functional Alterations in Early Stage of Coal Workers' Pneumoconiosis with Alcoholism: Insights from a resting-state fMRI investigation

Provisionally accepted
Boting  XueBoting Xue1Gang  CaoGang Cao1Lingling  RenLingling Ren1Yuxiang  ZhaoYuxiang Zhao1Xuecong  LvXuecong Lv1Yongai  LiYongai Li2Akifumi  HagiwaraAkifumi Hagiwara3,4Yongbo  LiuYongbo Liu1*Xiaowei  HanXiaowei Han5
  • 1Peking University lu'an Hospital, Changzhi, China
  • 2Department of Radiology, Changzhi People’s Hospital, Shanxi, Changzhi, China
  • 3Department of Radiology, School of Medicine, Juntendo University, Bunkyō, Tokyo, Japan
  • 4Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan
  • 5Department of Radiology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China

The final, formatted version of the article will be published soon.

Objectives: This study aimed to investigate resting-state functional magnetic resonance imaging (fMRI) changes in Coal Workers' Pneumoconiosis (CWP) patients with alcoholism using Amplitude of Low-Frequency Fluctuation (ALFF) and Functional Connectivity (FC) analyses.: A total of 60 patients with stage I CWP and 30 healthy controls were prospectively enrolled. The CWP patients were further divided into drinking and non-drinking groups. Resting-state fMRI scans were performed for all three groups, and correlations between abnormal ALFF signals, FC changes, and clinical baseline data were analyzed. Results: Compared to the control group, both the CWP drinking and non-drinking groups exhibited increased ALFF signals in the left orbitofrontal cortex, left frontal pole, right intracalcarine cortex, and right precuneus cortex, as well as decreased ALFF signals in the bilateral temporal pole and left occipital fusiform gyrus. Functional connectivity analysis revealed increased connectivity from the right orbitofrontal cortex to the right pars triangularis of the inferior frontal gyrus and from the right precuneus cortex to the right lingual gyrus in both CWP groups. Conversely, decreased connectivity was observed in the left and right frontal poles. Additionally, a positive correlation was found between ALFF values in the left temporal pole and PaO2 levels in the CWP drinking group (r=0.369, p=0.038). In the CWP non-drinking group, functional connectivity between the right precuneus cortex and the right lingual gyrus showed a negative correlation with FVC (r=-0.442, p=0.027).CWP patients with alcoholism exhibit abnormal brain regions and functional connectivity associated with spontaneous neural activity changes.Significant correlations between specific brain regions and clinical indicators were identified. These findings provide a foundation for understanding neuroimaging changes in CWP patients with alcoholism through fMRI.

Keywords: Coal worker's pneumoconiosis, Alcoholism, cognitive impairment, fMRI, Amplitude of Low-Frequency Fluctuation, Functional Connectivity

Received: 12 Apr 2025; Accepted: 02 Jun 2025.

Copyright: © 2025 Xue, Cao, Ren, Zhao, Lv, Li, Hagiwara, Liu and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Yongbo Liu, Peking University lu'an Hospital, Changzhi, China

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