ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Brain Imaging Methods
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1612271
Globus Pallidus Externus Correlates with Arousal in Disorders of Consciousness: A Resting-State Functional MRI Study
Provisionally accepted
- 1Department of Neurosurgery, Shaanxi Provincial People's Hospital,, Xi'an City, China
- 2Xi'an Medical University, Xi'an, China
- 3Department of MRI, Shaanxi Provincial People's Hospital, Xi’an, China
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The "Mesocircuit" model explains consciousness loss and recovery following severe brain injury as disconnection of cortical-subcortical circuits.Excessive inhibition of prefrontal cortex/thalamus by internal globus pallidus (GPi) is proposed as key to disorders of consciousness (DoC). However, recent research found external globus pallidus (GPe) crucial for arousal in DoC patients.To investigate the relationship between GPe and arousal, this study enrolled 50 patients with DoC who were admitted to the Department of Neurosurgery,
Keywords: disorders of consciousness, Arousal, Globus Pallidus Externus, Mesocircuit hypothesis, resting-state functional MRI, Function connectivity
Received: 15 Apr 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 秦, Li, Bai, Miao, Yang, Cui, Zhang and Miao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xingyu Miao, Department of Neurosurgery, Shaanxi Provincial People's Hospital,, Xi'an City, China
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