REVIEW article
Front. Neurosci.
Sec. Neurogenomics
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1622894
Epigenetic Remodeling: Unveiling the Potential Endogenous Mechanisms of Exercise in Alleviating Neuropathic Pain
Provisionally accepted
- 1Jiangsu Rongjun Hospital,Department of Clinical Laboratory, Wuxi, China
- 2Xuzhou Medical University, Xuzhou, China
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Although exercise can improve neuropathic pain (NP), its underlying mechanisms have not been elucidated completely. Epigenetics involves the study of environmental factors, such as diet, temperature, and exercise, and basic functions. NP can be improved by controlling the state of epigenetic modification. This article focuses on the exercise and epigenetic mechanisms of NP and discusses the progress of the research on epigenetic regulation in the field of exercise rehabilitation. The studies presented herein are not only used to facilitate the understanding of the important potential mechanisms of exercise for improving NP but also provide a new idea that NP can be improved by endogenous regulatory mechanisms.
Keywords: neuropathic pain, epigenetic, Exercise, Nerve injury, DNA Methylation
Received: 05 May 2025; Accepted: 22 Aug 2025.
Copyright: © 2025 Shan, Xu, Guo and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiabao Guo, Xuzhou Medical University, Xuzhou, China
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