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ORIGINAL RESEARCH article

Front. Neurosci.

Sec. Neurodevelopment

Volume 19 - 2025 | doi: 10.3389/fnins.2025.1623105

The Vermian-Crest Angle: a prediction model for foetal cystic posterior fossa anomalies

Provisionally accepted
Marialuigia SpinelliMarialuigia Spinelli1*Sofia Amylidi-MohrSofia Amylidi-Mohr1Daniel SurbekDaniel Surbek1Kai-Sven HelingKai-Sven Heling2Matthias ScheierMatthias Scheier3Léo PomarLéo Pomar4David BaudDavid Baud4Luigi RaioLuigi Raio1
  • 1University of Bern, Bern, Switzerland
  • 2Centre for Prenatal Diagnosis, Friedrichstrasse, Berlin, Germany, Berlin, Germany
  • 3Fetal medicine Service, Outpatient, Feldkirch, Austria
  • 4Lausanne University Hospital, lausanne, Switzerland

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The Vermian-Crest Angle: a prediction model for foetal cystic posterior fossa anomalies Condensation: The Vermian-Crest Angle evaluated by 3D ultrasound, accurately categorizes posterior fossa anomalies, differentiating Blake's pouch cysts from Dandy-Walker malformations with high sensitivity and specificity. Short Title: New categorisation of enlarged posterior fossa A. Why was this study conducted? Anomalies of the foetal posterior fossa can be challenging in the counselling of the future parents regarding prognosis. However, a dependable tool for an accurate diagnosis is still unknown. B. What are the key findings? The Vermian-Crest angle evaluated at three-dimensional ultrasound could be useful in addressing categorisation of posterior fossa anomalies. C. What does this study add to what is already known? This is among the few studies investigating the measurement of the vermian crest angle and its meaning in the foetal neurosonography.

Keywords: Vermian-crest angle, Posterior fossa, Vermis, Cerebellum, PrenatalDiagnosis, Three-Dimensional Ultrasound Scan, Blake pouch cyst, Dandy WalkerMalformation

Received: 05 May 2025; Accepted: 21 Aug 2025.

Copyright: © 2025 Spinelli, Amylidi-Mohr, Surbek, Heling, Scheier, Pomar, Baud and Raio. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Marialuigia Spinelli, University of Bern, Bern, Switzerland

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material