White Matter Hyperintensity Burden and Infarct Volume Predict Functional Outcomes in Anterior Choroidal Artery Stroke: A Multimodal MRI Study

Weiwei Gao^1,2,3Mingyang Wang¹Junyi Huang⁴Lijuan Cai^2,3Xingyu Chen^2,3Jianzhong Lin^2*Renjing Zhu^1,2,3*

• ¹Jimusaer County People's Hospital, Changji, China
• ²Zhongshan Hospital, Xiamen University, Xiamen, China
• ³Xiamen Clinical Research Center for Cerebrovascular Diseases, Xiamen, China
• ⁴Imperial College London, London, United Kingdom

Objective: To investigate the relationship between white matter hyperintensity (WMH) burden and infarct volume with functional outcomes in patients with anterior choroidal artery (AChA) territory infarction.Methods: This retrospective cohort study included patients with AChA territory infarction admitted to two comprehensive stroke centers between September 2018 and September 2024. WMH burden was assessed using the Fazekas visual rating scale and an automated volumetric quantification method based on lesion prediction algorithms. Acute infarct volume was precisely measured using fully automated threshold segmentation. Poor functional outcome was defined as a modified Rankin Scale (mRS) score ≥3 at 90 days. Associations were evaluated using multivariable logistic regression models with stepwise adjustment for confounders, and predictive performance was assessed using receiver operating characteristic curve analysis. Restricted cubic spline (RCS) regression was employed to explore non-linear associations, followed by piecewise regression analysis based on threshold effects.Results: A total of 216 patients were included, of whom 73 (33.80%) had poor functional outcomes at 90 days. After adjusting for potential confounders, both WMH burden and infarct volume were independently associated with poor functional outcomes at 90 days, with infarct volume demonstrating superior predictive performance (AUC: 0.80 vs. 0.67). For each 1-mL increase in WMH volume, the risk of poor outcomes increased by 2% (adjusted OR=1.02, 95% CI: 1.01-1.03, P=0.032). RCS analysis revealed a nonlinear association between infarct volume and poor outcomes, with a threshold of 2.7 mL. When infarct volume was below this threshold, each 1-mL increase in infarct volume was associated with a 5.31-fold increased risk of poor outcomes (adjusted OR=5.31, 95% CI: 3.07-9.73; standardized OR=3.03, 95% CI: 2.11-4.53).In patients with AChA territory infarction, both WMH burden and infarct volume can independently predict functional outcomes at 90 days. Infarct volume exhibits a nonlinear association with outcomes, with a critical threshold of 2.7 mL identified.