ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Brain Imaging Methods
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1629878
Gray Matter Volume Microstructural Alterations in Chronic Post-burn Pruritus: A Voxel-Based Morphometry Analysis Using 3D T1-Weighted Imaging
Provisionally accepted
- 1General Hospital of Tisco, Taiyuan, China
- 2Tongji University, Shanghai, China
- 3Shanxi Medical University, Taiyuan, China
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Background: Chronic post-burn pruritus (CPBP) refers to a highly prevalent as well as debilitating problem after burn injuries, substantially impairing patients' quality of life. Nevertheless, the precise pathological mechanisms underlying CPBP remain elusive. The present study seeks to investigate microstructural changes in gray matter among individuals with CPBP and to evaluate associations between these changes and clinical scale scores via voxel-based morphometry (VBM).We recruited 20 people having CPBP and 20 healthy controls (HCs) who were of the same sex and age. T1-weighted imaging in three dimensions (3D-T1WI) was performed on each participant. Using VBM, volumes of gray matter in each region were measured. Volume differences between groups were measured, and it was methodically examined how the volume in particular brain regions correlated with clinical markers.We found no discernible age difference between the groups (P > 0.05).Compared with HCs, patients with CPBP showed reduced gray matter volume across multiple brain regions (P < 0.05). These regions encompassed the bilateral parahippocampal gyri, right medial frontal gyrus, right middle frontal gyrus, left cerebellum posterior lobe, left fusiform gyrus, left superior occipital gyrus, left middle temporal gyrus, left cuneus, inferior parietal lobule, right medial frontal gyrus, and left superior temporal gyrus. Furthermore, correlation analysis showed a negative relationship between the individuals' Self-Rating Depression Scale scores and the gray matter volume in the right superior temporal gyrus in patients with CPBP (r = -0.632, P = 0.003).The frontal, temporal, parietal, occipital, and cerebellar regions all exhibit a marked reduction in volume in response to CPBP.
Keywords: chronic post-burn pruritus, voxel-based morphometry analysis, 3D T1-weighted imaging, Microstructural changes, gray matter volume
Received: 16 May 2025; Accepted: 21 Aug 2025.
Copyright: © 2025 Lu, Li, Huang, Guo, Bai, Liu, Zhu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhikai Lu, General Hospital of Tisco, Taiyuan, China
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