Correction: Fingolimod Inhibits Inflammation but Exacerbates Brain Edema in the Acute Phases of Cerebral Ischemia in Diabetic Mice

Wanlu LITingting HeLu JiangRubing ShiYaying SongMuyassar MamtilahunMa YuanyuanZhijun ZhangYaohui TangGuoyuan Yang^*Yongting Wang

• Shanghai Jiao Tong University, Shanghai, China

Correction: Fingolimod Inhibits Inflammation but Exacerbates Brain Edema in the Acute Phases of Cerebral Ischemia in Diabetic Mice* Correspondence: ytwang@sjtu.edu.cn or gyyang0626@163.comKeywords: Diabetic stroke, diabetes mellitus, fingolimod, edema, inflammation.Correction on: Wanlu Li, Tingting He, Lu Jiang, Rubing Shi, Yaying Song, Muyassar Mamtilahun, Yuanyuan Ma, Zhijun Zhang, Yaohui Tang, Guoyuan Yang*, Yongting Wang*. Fingolimod inhibits inflammation but exacerbates brain edema in the acute phases of cerebral ischemia in diabetic mice. Frontiers in neuroscience, 2020, 14: 842. Error in figure/tableIn the published article, there was an error in Figure 3C as published. The GAPDH western blot image in Figure 3C was unintentionally incorrectly used. The corrected Figure 3C and its caption ** Figure 3. Fingolimod increased Bcl-2/Bax ratio but did not reduce the number of TUNEL + cells at 24 h after tMCAO. (A), Micrographs of TUNEL staining in the peri-infarct region of DM + MCAO and DM + MCAO + F groups. Scale bar, 50 μm. Left panel showing the sketch of the brain section, boxes in it illustrating fields we are sampling in. (B), Bar graph is the quantification of the number of TUNEL+ cells in DM + MCAO and DM + MCAO + F groups (n = 3/group). (C), Western blot results of apoptotic factors Bcl-2 and Bax. (D), Bar graph is the quantification of Bcl-2/Bax ratio based on Western blot data [n (Sham) = 3, n (DM + MCAO) = 3, n (DM + MCAO + F) = 6]. MW, molecular weight. Data are presented as mean ± SEM, *p < 0.05, **p < 0.01. appear below.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.Text correctionIn the published article, there was an error. Citing data within the Results section.A correction has been made to Results, Acute Treatment with Fingolimod Failed to Improve Endpoint Outcomes at 24 h After tMCAO in Diabetic Mice, Paragraph 2-Reuslt of Figure 1G. This sentence previously stated:“brain infarction volume (DM + MCAO vs. DM + MCAO + F, 62.81 ±3.15 mm3 vs. 71.22 ±3.98 mm3) (Figures 1F–G) was observed.”The corrected sentence appears below:“brain infarction volume (DM + MCAO vs. DM + MCAO + F, 40.7 ± 8.90 mm3 vs. 34.4 ± 6.97 mm3) (Figures 1F–G) was observed.”The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.