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CORRECTION article

Front. Neurosci., 01 July 2025

Sec. Neurodegeneration

Volume 19 - 2025 | https://doi.org/10.3389/fnins.2025.1641304

Correction: Reduction of the RNA binding protein TIA1 exacerbates neuroinflammation in tauopathy

This article is a correction to:

  1. Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy

    1. Read original article
Chelsey Jenna LeBlangChelsey Jenna LeBlang1Maria MedallaMaria Medalla1Nicholas William NicolettiNicholas William Nicoletti1Emma Catherine HaysEmma Catherine Hays1James ZhaoJames Zhao1Jenifer ShattuckJenifer Shattuck2Anna Lourdes CruzAnna Lourdes Cruz2Benjamin Wolozin,,&#x;Benjamin Wolozin2,3,4†Jennifer Irene Luebke &#x;Jennifer Irene Luebke1*†
  • 1Laboratory of Cellular Neuroscience, Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, United States
  • 2Laboratory of Neurodegeneration, Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States
  • 3Department of Neurology, Boston University School of Medicine, Boston, MA, United States
  • 4Department of Neuroscience, Boston University, Boston, MA, United States

A Correction on
Reduction of the RNA binding protein TIA1 exacerbates neuroinflammation in tauopathy

by LeBlang, C. J., Medalla, M., Nicoletti, N. W., Hays, E. C., Zhao, J., Shattuck, J., Cruz, A. L., Wolozin, B., and Luebke, J. I. (2020). Front. Neurosci. 14:285. doi: 10.3389/fnins.2020.00285

There was a mistake in Figure 4D, Row 2, Column 4 as published. P301S +/+ 9M image was duplicated in error under P301S TIA1 -/- 9M. The corrected Figure 4 appears below.

Figure 4
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Figure 4. Reduction of TIA1 increases expression of mRNAs associated with microglial phagocytosis and increases synapse loss in advanced tauopathy. (A) log2 fold change of C1qa expression in WT TIA1+/+ vs. P301S TIA1+/+, P301S TIA1+/−, and P301S TIA1−/− at 5 months (light gray) and 9 months (dark gray). n = 3 subjects/genotype. (B) log2 fold change of C3 expression in WT TIA1+/+ vs. P301S TIA1+/+, P301S TIA1+/−, and P301S TIA1−/− at 5 months (light gray) and 9 months (dark gray). n = 3 subjects/genotype. (C) log2 fold change of TREM2 expression in WT TIA1+/+ vs. P301S TIA1+/+, P301S TIA1+/−, and P301S TIA1−/− at 5 months (light gray) and 9 months (dark gray). n = 3 subjects/genotype. (D) High resolution (40×) confocal maximum projection images depicting Synaptophysin (SYP, red) in the apex of the dentate gyrus including the dorsal and ventral dentate granule cell layers and hilus in WT TIA1+/+ and P301S subjects that are TIA1+/+, TIA1+/−, and TIA1−/− at 5 months (top) and 9 months (bottom). Scale = 25 μm. (E) Average size of SYP particles in (D), 5 months (light gray) and 9 months (dark gray). n = 9–12 fields, from 3 to 4 animals/genotype. (F) Percent Area occupied by SYP particles in (D), 5 months (light gray) and 9 months (dark gray). n = 9–12 fields, from 3 to 4 animals/genotype. (G) Electron photomicrographs at 20k × depicting synapses (Presynaptic structures in red, B, bouton; Ax, axon; Postsynaptic structures in blue, D, dendrite; Sp, spine; Synaptic contacts = white arrowheads) in the dentate gyrus hilus neuropil in WT TIA1+/+ and P301S subjects that are TIA1+/+, TIA1+/−, and TIA1−/− animals. Scale = 1 μm. (H) Average density of excitatory (light gray) and inhibitory (dark gray) synapses in the dentate gyrus hilus neuropil in WT TIA1+/+ and P301S TIA1+/+, TIA1+/−, and TIA1−/− animals. (n = 3–4 fields, from 1 animal/genotype, no statistical analyses performed, qualitative data). All statistical comparisons calculated with One-Way ANOVA with Bonferroni post hoc test, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.

The original article has been updated.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: tauopathy, neuroinflammation, microglia, hippocampus, RNA binding protein, neurodegeneration

Citation: LeBlang CJ, Medalla M, Nicoletti NW, Hays EC, Zhao J, Shattuck J, Cruz AL, Wolozin B and Luebke JI (2025) Correction: Reduction of the RNA binding protein TIA1 exacerbates neuroinflammation in tauopathy. Front. Neurosci. 19:1641304. doi: 10.3389/fnins.2025.1641304

Received: 04 June 2025; Accepted: 12 June 2025;
Published: 01 July 2025.

Edited and reviewed by: Efthimios M. C. Skoulakis, Alexander Fleming Biomedical Sciences Research Center, Greece

Copyright © 2025 LeBlang, Medalla, Nicoletti, Hays, Zhao, Shattuck, Cruz, Wolozin and Luebke. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Jennifer Irene Luebke, amx1ZWJrZUBidS5lZHU=

†These authors share senior authorship

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.