ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Auditory Cognitive Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1647513
This article is part of the Research TopicAge-Related Hearing Loss: From Pathogenesis to Therapy and Psychiatric ImpactView all articles
Age Effect on Inter-Pulse Interval Selection for ECAP Measurement
Provisionally accepted
- 1Second Hospital of Anhui Medical University, Hefei, China
- 2First Affiliated Hospital of Soochow University, Suzhou, China
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Age and duration of deafness significantly affect the auditory nerve (AN) health of cochlear implant (CI) users. In this study, we examine how age and duration of deafness impact Electrically Evoked Compound Action Potential (ECAP) amplitudes when the Inter-Pulse Interval (IPI) parameter in ECAP measurements is varied. Our participants were thirty-one Mandarin-speaking CI users with Nurotron/CS-20A (19 males and 12 females, 33 ears, aged 6-66 yrs). We investigated eleven distinct IPI settings, ranging from 290 μs to 590 μs (IPI = 290, 330, 350, 390, 410, 450, 470, 510, 530, 570, 590 μs). The first result of our study was to find the optimal IPI of the participants. Furthermore, the optimal IPI was positively correlated with both the age of the participants (r = 0.6018, p = 0.0002) and the duration of deafness (r = 0.3479, p = 0.0473). These results highlight the significant influence of age and duration of deafness on the determination of optimal IPI in CI users. In summary, our study sheds light on the pivotal role of age and duration of deafness in ECAP amplitudes and optimizing IPI settings. We recommend that CI users with advanced age and long duration of deafness use longer IPI parameters for ECAP measurements to obtain a more accurate ECAP waveform. These insights hold significant implications for tailoring CI programming and rehabilitation strategies to cater to the distinct needs of individuals across different ages and duration of deafness groups, ultimately enhancing the auditory experiences and outcomes of CI users.
Keywords: cochlear implant, Electrically evoked compound action potential, Inter-pulseInterval, age, Nurotron
Received: 15 Jun 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Wu, Yang, Liang and yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jian-ming yang, Second Hospital of Anhui Medical University, Hefei, China
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