SYSTEMATIC REVIEW article
Front. Neurosci.
Sec. Neurodegeneration
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1652196
Emerging Regenerative Strategies for Spinal Cord Injury: Exosome-Derived Mechanisms and Therapeutic Insights
Provisionally accepted
- 1First Hospital of Shanxi Medical University, Taiyuan, China
- 2Shanxi Medical University, Taiyuan, China
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Spinal cord injury (SCI) often leads to severe motor and sensory impairments, and current treatment methods have not achieved complete neural repair. In recent years, exosomes have become a research focus in the treatment of nerve injuries due to their important roles in intercellular information transfer, immune regulation, and neural repair. Our study conducts a scientometric analysis to map the research landscape related to exosomes in SCI.Articles and reviews related to exosome in SCI were retrieved from the Web of Science Core Collection and Scopus. Analysis was conducted using Microsoft Excel 2021, CiteSpace (6.4.R1), VOSviewer (1.6.18), the R software (4.4.3) bibliometrix package,etc.Since 2018, the number of publications has rapidly increased. Fan Jin is the most academically influential author in the field, while Cai Weihua's research has received widespread recognition from researchers. China is the leading contributor among the 32 countries/regions. Among the 708 institutions, Central South University and Zhejiang University are the primary supporters. Journal of Nanobiotechnology is the most influential journal in this field, with Neural Regeneration Research and Cells also making significant contributions. Keyword analysis focuses on "mesenchymal stem cells", "inflammation", "cell therapy", "axonal regeneration", "functional recovery", "neuroinflammation", "neurodegeneration", " ferroptosis ", "pyroptosis" and "precision medicine" emphasizing cellular therapies for tissue repair. Emerging topics like "nanoparticles" show significant potential in SCI treatment, further enhancing regenerative medicine approaches.Our study show that the growing global interest in exosome-based therapies for SCI, marking an important step in understanding their preclinical potential.These therapies show promise in promoting neuroprotection, axonal regeneration, and modulating inflammation. Moving forward, future research will focus on further exploring the integration of exosome therapies with advanced drug delivery systems and regenerative medicine, aiming to enhance SCI treatments and tailor recovery strategies in preclinical models.
Keywords: spinal cord injury, Exosomes, Inflammation, Neuroprotection, Mesenchymal Stem Cells
Received: 23 Jun 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Fan, Gao, Chen, Sun, Guo, Xiaodong and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liu Xiaodong, First Hospital of Shanxi Medical University, Taiyuan, China
Jinhu Li, First Hospital of Shanxi Medical University, Taiyuan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.