There was a mistake in Figure 2 as published. Incorrect images were used in Figure 2A. The corrected Figure 2 appears below.
Figure 2
DAPK1 was identified as a target gene of miR-124. DAPK1 levels were measured by western blotting (A) and quantitatively analyzed (B, C). Data are presented as mean ± SD (n = 4/group). **p < 0.01, ***p < 0.001 vs. Con or Sham group. N2a cells were transfected with miR-124 (oe-miR-124) or control-treated (oe-control) cells. Levels of miR-124 and DAPK1 mRNA were measured by qRT-PCR (D). Levels of DAPK1, caspase-3, cleaved caspase-3, p35/25, ERK1/2, and p-ERK1/2 were measured by western blotting (E) and quantitatively analyzed (F). Data are presented as mean ± SD (n = 4/group). **p < 0.01, ***p < 0.001 vs. oe-control group.
There was a mistake in Figure 4 as published. Incorrect images were used in Figure 4A. The corrected Figure 4 appears below.
Figure 4
miR-124 protected against PIT-stroke damage. (A) TUNEL staining was performed in primary cultured neurons after OGD treatment with different miR-124 levels (scale bar = 50 μm) and quantified (B). Data are presented as mean ± SD (n = 4/group). **p < 0.01 vs. Con, ##p < 0.01 vs. OGD group. (C) Representative images of TTC staining depicting Ago-miR-124-induced protection against PIT-stroke damage. Levels of DAPK1, caspase-3, and cleaved caspase-3 were measured by western blotting (D) and quantitatively analyzed (E). Neurological scores (F) and performance on the rotarod test (G) were tested on day 1, day 3, and day 7 after PIT-stroke among different groups. Data are presented as mean ± SD (n = 6/group). **p < 0.01, ***p < 0.001 vs. Sham, #p < 0.05, ##p < 0.01 vs. PIT-stroke group.
The original version of this article has been updated.
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Summary
Keywords
stroke, cell death, miR-124, DAPK1, neuron
Citation
Shi Y, Tian T, Cai E-L, Yang C and Yang X (2025) Correction: miR-124 alleviates ischemic stroke-induced neuronal death by targeting DAPK1 in mice. Front. Neurosci. 19:1657393. doi: 10.3389/fnins.2025.1657393
Received
01 July 2025
Accepted
31 October 2025
Published
17 November 2025
Volume
19 - 2025
Edited and reviewed by
Mark P. Burns, Georgetown University, United States
Updates
Copyright
© 2025 Shi, Tian, Cai, Yang and Yang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Xin Yang, yangxin@siat.ac.cn
†These authors have contributed equally to this work
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.