Pablo Bonilla
Alexandria Shanks
Alessandra Porcu- Department of Drug Discovery and Biomedical Science, University of South Carolina, Columbia, SC, United States
A Correction on
Effects of chronic light cycle disruption during adolescence on circadian clock, neuronal activity rhythms, and behavior in mice
by Bonilla, P., Shanks, A., Nerella, Y., and Porcu, A. (2024). Front. Neurosci. 18:1418694. doi: 10.3389/fnins.2024.1418694
There was a mistake in Figure 3C as published. The panel labeled as Control-ZT22 was inadvertently duplicated from the LCD-ZT2 image. The panel labeled as Control-ZT16 was incorrectly selected and actually corresponds to Control-ZT22. This mistake occurred during figure assembly due to confusion while selecting representative figures from our blinded dataset. All data analyses and quantifications were conducted using the correct images, and we have verified that the conclusions of Per1 analysis remain valid and unaffected. The corrected Figure 3 appears below.
Figure 3. Daily expression of Per1, Clock and cFOS in the SCN. Representative confocal micrographs showing (A) Clock (red) and (C) Per1 (green) mRNA expression detected by RNAscope and (E) c-FOS (red) detected by immunofluorescence at ZT2, ZT8, ZT16 and ZT22 in control and LCD mice (Scale bar 50 μm). Line graphs show (B) Clock mRNA expression (F1, 32 = 76.41, p < 0.0001 by two-way ANOVA with Šídák's multiple comparison posttest) and (D) Per1 mRNA expression [F(1, 32) = 10.17, p < 0.0032 by two-way ANOVA with Šídák's multiple comparison posttest] determined by semiquantitative scoring of Clock and Per1 dots and clusters per neuron, and (F) number of c-FOS positive neurons in the SCN [F(1, 32) = 38.01, p < 0.0001 by two-way ANOVA with Šídák's multiple comparison posttest]. Data are shown as mean ± SEM. (Control n = 2 females and n = 2 males; LCD n = 2 females, n = 2 males) for the SCN in a 30-μm section; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, two-way ANOVA (post-hoc test conducted with Šídák's multiple comparison test).
The original version of this article has been updated.
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Keywords: light cycle disruption, suprachiasmatic nucleus, dentate gyrus, medial amygdala, somatostatin, clock genes, neuronal activity, avoidance behavior
Citation: Bonilla P, Shanks A, Nerella Y and Porcu A (2025) Correction: Effects of chronic light cycle disruption during adolescence on circadian clock, neuronal activity rhythms, and behavior in mice. Front. Neurosci. 19:1664442. doi: 10.3389/fnins.2025.1664442
Received: 11 July 2025; Accepted: 14 August 2025;
Published: 08 September 2025.
Edited and reviewed by: Chelsea A. Vadnie, Ohio Wesleyan University, United States
Copyright © 2025 Bonilla, Shanks, Nerella and Porcu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Alessandra Porcu, YXBvcmN1QG1haWxib3guc2MuZWR1