Jiaqi Shen1Li Xu1Yuxuan Li1Weichen Dong2
Jing Cai3Yutong Liu1Hongting Zhao1Tianze Xu3
Esther Meyron Holtz4Yanzhong Chang5
Tong Qiao3*
Kuanyu Li1*- 1Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- 2Department of Neurology, The Affiliated Jinling Hospital of Nanjing University Medical School, Nanjing, China
- 3Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
- 4The Laboratory of Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion – Israel Institute of Technology, Haifa, Israel
- 5College of Life Science, Hebei Normal University, Shijiazhuang, China
A Correction on
Protective effects of Hif2 inhibitor PT-2385 on a neurological disorder induced by deficiency of Irp2
by Shen, J., Xu, L., Li, Y., Dong, W., Cai, J., Liu, Y., Zhao, H., Xu, T., Holtz, E. M., Chang, Y., Qiao, T., and Li, K. (2021). Front. Neurosci. 15:715222. doi: 10.3389/fnins.2021.715222
There was a mistake in Figure 3 as published. One image was wrongly used in Figure 3B (left middle one), which is the same as in Figure 3C (right middle one). The corrected Figure 3 appears below.
Figure 3. The histological morphology and mitochondrial ultrastructure in the spinal cord and cerebellum of Irp2−/− mice are improved after PT-2385 administration. (A) The hematoxylin–eosin (H&E)-stained sections of the cerebellum of WT DMSO, Irp2−/− DMSO, and Irp2−/− PT-2385 mice. The dotted lines indicate Purkinje cell layers (top), and the arrows point to Purkinje cells (middle). The Purkinje cells framed by the dotted line are magnified four times (bottom). The scale bars are 160, 80, and 20 μm, respectively. (B, C) Transmission electron micrographs of the cerebellum (B) and spinal cord (C) of WT DMSO, Irp2−/− DMSO, and Irp2−/− PT-2385 mice. The scale bars are 1, 2.5, and 5 μm, respectively. The bottom panels are magnified images of myelin sheath and axonal degeneration. (D) The quantification of a normal mitochondria (relative ratio comparing with that in WT). Values represented the mean ± SD, n = 3. The ANOVA was used for statistics to evaluate the group differences. *P < 0.05, ****P < 0.0001, Irp2−/− DMSO vs. WT DMSO; #P < 0.05, ##P < 0.01, Irp2−/− PT-2385 vs. Irp2−/− DMSO.
The original version of this article has been updated.
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Keywords: iron regulatory protein 2, hypoxia inducible factor 2α, glycolysis, oxidative phosphorylation, iron sulfur cluster, neurodegeneration
Citation: Shen J, Xu L, Li Y, Dong W, Cai J, Liu Y, Zhao H, Xu T, Holtz EM, Chang Y, Qiao T and Li K (2025) Correction: Protective effects of Hif2 inhibitor PT-2385 on a neurological disorder induced by deficiency of Irp2. Front. Neurosci. 19:1667076. doi: 10.3389/fnins.2025.1667076
Received: 16 July 2025; Accepted: 07 August 2025;
Published: 29 August 2025.
Edited and reviewed by: David Lynch, University of Pennsylvania, United States
Copyright © 2025 Shen, Xu, Li, Dong, Cai, Liu, Zhao, Xu, Holtz, Chang, Qiao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Kuanyu Li, bGlrdWFueXVAbmp1LmRldS5jbg==; Tong Qiao, dG9uZ3FpYW9Abmp1LmVkdS5jbg==