REVIEW article
Front. Neurosci.
Sec. Neuropharmacology
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1670516
This article is part of the Research TopicNovel Pharmacological Interventions in Emotional and Neuropsychiatric DisordersView all 6 articles
Study on the Protective Effects and Mechanisms of Eleutherococcus Senticosus on Korsakoff Syndrome
Provisionally accepted
Ning Zhang*
Shan JiangYao ai WangYi fan RenXiao ran SunJia xin DingSi ju LouXue ke Bai
Xin Hai*Galina Ramenskaya*- Heilongjiang University of Chinese Medicine, Harbin, China
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Korsakoff syndrome (KS), as a central nervous system disorder caused by prolonged alcohol exposure, is primarily characterized by cognitive dysfunction, which has long-term effects on patients' lives, and there is currently a lack of effective therapeutic drugs. Eleutherococcus senticosus (ES), as a traditional medicinal plant, has significant antioxidant, anti-inflammatory, and central nervous system protective effects, and is widely used as ethnopharmacological agen. This article elaborates on the main pathogenesis and the latest research progress of KS, summarizes the mechanisms of central nervous system protection by ES and its active components, and explores its main mechanisms and targets for treating KS, aiming to provide drug options for the effective treatment of KS while promoting the development and utilization of the medicinal value of ES.
Keywords: Korsakoff Syndrome, cognitive dysfunction, Eleutherococcus senticosus, Central Nervous System, alcohol
Received: 21 Jul 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Zhang, Jiang, Wang, Ren, Sun, Ding, Lou, Bai, Hai and Ramenskaya. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ning Zhang, Heilongjiang University of Chinese Medicine, Harbin, China
Xin Hai, Heilongjiang University of Chinese Medicine, Harbin, China
Galina Ramenskaya, Heilongjiang University of Chinese Medicine, Harbin, China
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