ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Translational Neuroscience
This article is part of the Research TopicRecent Advances in Translational Neurovascular and Cerebroprotection ResearchView all 8 articles
Expression of Dementia Biomarkers in Appalachian and Non-Appalachian ELVO Patients during Thrombectomy
Provisionally accepted
Neha Anil1*
Christopher McLouth2,3
Hunter S Hazelwood1
Jacqueline Frank2,4Nathan Millson2Mais Al-Kawaz2
Jordan Patrick Harp2,4Will Cranford1Shivani Pahwa2,5
David Dornbos III6,7Elise Dahlke6
Justin F Fraser8
Keith Pennypacker9*- 1College of Medicine, University of Kentucky, Lexington, United States
- 2Department of Neurology, University of Kentucky, Lexington, United States
- 3Department of Biostatistics, University of Kentucky, Lexington, United States
- 4Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, United States
- 5Department of Neurosurgery, Department of Radiology, University of Kentucky, Lexington, United States
- 6Department of Neurosurgery, University of Kentucky, Lexington, United States
- 7Department of Radiology, University of Kentucky, Lexington, United States
- 8Department of Neurology, Department of Neurosurgery, Department of Radiology, Department of Neuroscience, Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, United States
- 9Department of Neurology, Department of Neuroscience, Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, United States
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Vascular Cognitive Impairment and Dementia (VCID) a8ects 25-30% of stroke patients and includes cognitive impairments caused by vascular injury, such as post-stroke dementia. Rehabilitation has the potential to improve the quality of life for patients at risk of developing dementia. However, there is currently no reliable method to identify those at risk of dementia after a stroke. Several biomarkers, including ADRD (Alzheimer's disease and related dementias) biomarkers have been associated with the development of dementia. Populations in Appalachia experience a higher incidence of stroke and related mortality compared to other groups. Given the elevated stroke rates in Appalachian communities, this study aims to investigate potential proteomic di8erences between patients from Appalachian and non-Appalachian counties. The primary goal of the study is to characterize the expression of post-stroke cognitive dementia biomarkers and to explore di8erences in the proteomic profiles of Appalachian and non-Appalachian populations.
Keywords: Appalachia, Stroke, VCID, Dementia, post stroke cognitive impairment (PSCI), biomarkers
Received: 24 Jul 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Anil, McLouth, Hazelwood, Frank, Millson, Al-Kawaz, Harp, Cranford, Pahwa, Dornbos III, Dahlke, Fraser and Pennypacker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Neha Anil, nan256@uky.edu
Keith Pennypacker, keith.pennypacker@uky.edu
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