ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Neurodegeneration
Neuroprotective eco-friendly iron oxide nanoparticles to alleviate Parkinson's disease symptoms and improve nursing care
Provisionally accepted
Shuangyan Chen
Ting Jiang*- College of Clinical Medicine, Brain Hospital of Hunan Province (The Second Hospital of Hunan Province), Hunan University of Chinese Medicine, Changsha, China
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The goal of this study is to find out how iron oxide nanoparticles (IONPs) protect against motor impairment and neurochemical changes in a rat model of Parkinson's disease (PD) in order to improve nursing care. We synthesized the IONPs using the green chemistry approach and characterized them using TEM imaging, UV-Vis spectroscopy, photoluminescence spectroscopy, XRD, and VSM techniques. We evaluated the antioxidant and biocompatibility of the IONPs using the DPPH assay and the MTT assay, respectively. It was found that the IONPs are spherical and have a size of 39.0 ± 11.3 nm. They also have a zeta potential of -13 mV and a high saturation magnetization value of 42.32 emu/gm. The in vitro biological tests showed that the IONPs had concentration-dependent antioxidant activity against DPPH free radicals and, up to 10 µg/mL, did not cause significant cell death or hemolysis. The animal studies on the MPTP-induced mouse model of PD revealed that IONPs ameliorated motor impairment by increasing antioxidant capacity and protecting DA-producing neurons from apoptosis. These results suggest that the biosynthesized IONPs could be considered a complementary treatment for PD.
Keywords: Parkinson's disease, Nursing Care, neuroprotective, Eco-friendly, Iron oxide nanoparticles
Received: 26 Aug 2025; Accepted: 20 Nov 2025.
Copyright: © 2025 Chen and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ting Jiang, tingjiang001@outlook.com
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