MINI REVIEW article
Front. Neurosci.
Sec. Translational Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1698056
This article is part of the Research TopicResearch on the Correlative Mechanisms and Clinical Exploration of Headache and Cerebrovascular DiseasesView all 4 articles
Reversible Cerebral Vasoconstriction Syndrome– Related Headache and Delayed Cerebral Infarction A Mini Review
Provisionally accepted- 1National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
- 2First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 3HeCares Integrative Medicine Center, Sunnyvale, United States
- 4ProCare acupuncture and wellness, Fairfax, United States
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Reversible cerebral vasoconstriction syndrome is a major cause of thunderclap headache and a preventable source of delayed ischaemic stroke. Despite expanding recognition, diagnosis is often delayed because early neuroimaging may be normal and vasoconstriction peaks in weeks two to three, and management remains experience-based rather than trial-anchored. In this mini-review we summarise advances in clinicoradiological definition and pathophysiology of tone dysregulation, outline risk-stratified diagnostic pathways built on serial CTA/MRA with confirmatory DSA when needed, high-resolution vessel-wall MRI to exclude inflammatory arteriopathy, perfusion MRI/CT and arterial spin labelling, and bedside transcranial Doppler, and appraise translational opportunities spanning time-anchored surveillance, perfusion-preserving care bundles and pragmatic endpoints. We also discuss enduring challenges—including nosological overlap with primary CNS vasculitis, non-standardised imaging schedules, heterogeneous blood-pressure targets and a paucity of randomised data—that temper implementation. By integrating time-aware vascular and perfusion readouts (e.g., planned week-2–3 repeat angiography, ASL hypoperfusion mapping, sustained Doppler velocities) with trigger withdrawal, cautious blood-pressure management and symptomatic vasodilators such as calcium-channel blockers and magnesium in selected contexts, emerging strategies aim to preserve cerebral perfusion, anticipate delayed infarction and standardise follow-up across settings. Our synthesis provides an appraisal of the evolving landscape of RCVS care and outlines pragmatic standards and avenues for prospective evaluation. We hope these insights will assist researchers and clinicians as they endeavour to implement more effective, individualised regimens.
Keywords: Reversible cerebral vasoconstriction syndrome, Thunderclap headache, Delayed cerebral infarction, Watershed infarct, Angiography, Calcium-channel blocker
Received: 03 Sep 2025; Accepted: 02 Oct 2025.
Copyright: © 2025 Zhang, He, Zhang, Zhu, Jin and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jin Yang, yangjin99123@163.com
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