PERSPECTIVE article
Front. Neurosci.
Sec. Brain Imaging Methods
This article is part of the Research TopicPushing boundaries with ultra-high field MRI: innovations and applications in neuroscienceView all 8 articles
Future Prospects for Image-Derived Input Function in Molecular Im-aging Quantification with the 7T MR-BrainPET Insert
Provisionally accepted
Cláudia Régio Brambilla1*
Julia Hilgers1
Usman Khalid1Ninea Anasovi2Tornike Kikacheishvili3
Jörg Mauler1
Chang-Hoon Choi1
Juergen Scheins1
Jon Shah1,4,5,6
Christoph W Lerche1- 1INM-4 Forschungszentrum Jülich GmbH, Jülich, Germany
- 2Agricultural University of Georgia, Tbilisi, Georgia
- 3Georgian American University, Tbilisi, Georgia
- 4Department of Radiology RWTH Aachen University, Aachen, Germany
- 5INM-11 Forschungszentrum Jülich GmbH, Jülich, Germany
- 6JARA-Brain Aachen, Aachen, Germany
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Positron emission tomography (PET) and magnetic resonance imaging (MRI) offer complementary information about the human brain in health and disease. The simultaneous 7T MR-BrainPET insert enables molecular imaging quantification beyond the current limits. Here we present the current status of the field highlighting PET/MR synergies for the image-derived input function (IDIF). We also discuss promising applications that will benefit from these advancements, as well the challenges to be addressed in the near future.
Keywords: UHF 7T MR, BrainPET 7T insert, Molecular Imaging, Neuroimaging, Image-derived input function, PET quantification
Received: 15 Oct 2025; Accepted: 01 Dec 2025.
Copyright: © 2025 Régio Brambilla, Hilgers, Khalid, Anasovi, Kikacheishvili, Mauler, Choi, Scheins, Shah and Lerche. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Cláudia Régio Brambilla
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